BMP8B Human
Description
BMP8B is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
For short-term storage (2-4 weeks), the product can be stored at 4°C. For extended storage, it is recommended to store the protein at -20°C. The addition of a carrier protein (0.1% HSA or BSA) is advised for long-term storage.
Repeated freeze-thaw cycles should be avoided.
Product Science Overview
Bone Morphogenetic Protein-8b (BMP8B) is a member of the Transforming Growth Factor-beta (TGF-β) superfamily, which plays a crucial role in bone and cartilage development. BMP8B is encoded by the BMP8B gene located on human chromosome 1p34.2 . This protein is known for its ability to induce ectopic bone growth and is closely related to BMP5 and BMP7 .
BMP8B is a secreted signaling molecule that functions as a cytokine. It binds to TGF-β receptors, leading to the recruitment and activation of SMAD family transcription factors, which regulate gene expression . The protein is initially synthesized as a preproprotein, which is proteolytically processed to generate each subunit of the disulfide-linked homodimer .
BMP8B has several important biological functions:
- Bone and Cartilage Development: BMP8B plays a significant role in the formation of bone and cartilage. It is believed to be the osteoinductive factor responsible for epithelial osteogenesis .
- Thermogenesis: BMP8B stimulates thermogenesis in brown adipose tissue, which is crucial for maintaining body temperature .
- Calcium Regulation: It also plays a role in calcium regulation and bone homeostasis .
Recombinant BMP8B is used in various research and clinical applications. It is produced using recombinant DNA technology, typically expressed in E. coli . This recombinant protein is valuable for studying bone and cartilage development, as well as for potential therapeutic applications in bone-related disorders.
