BMP8B Antibody

Bone Morphogenetic Protein-8b (BMP-8b) is a member of the Transforming Growth Factor-beta (TGF-β) superfamily, which plays a crucial role in the regulation of bone and cartilage development, as well as other cellular processes. BMP-8b is encoded by the BMP8B gene and is involved in various physiological and pathological processes.

The BMP8B gene encodes a secreted ligand of the TGF-β superfamily. This gene undergoes proteolytic processing to generate each subunit of the disulfide-linked homodimer . The mature BMP-8b protein has a molecular weight of approximately 16 kDa, while the precursor form is around 45 kDa .

BMP-8b is known to induce cartilage and bone formation, making it a critical factor in skeletal development and repair . It also plays a role in calcium regulation and bone homeostasis. In mice, BMP-8b is expressed in male germ cells of the testis and trophoblast cells of the placenta, suggesting its involvement in spermatogenesis and reproduction .

BMP-8b has been associated with various diseases, including ethmoid sinus cancer and sialolithiasis . Its expression may be downregulated in pancreatic cancer, indicating a potential role in tumorigenesis . Additionally, BMP-8b stimulates thermogenesis in brown adipose tissue, highlighting its importance in energy metabolism .

The mouse anti-human BMP-8b antibody is a polyclonal antibody that detects BMP-8b in both human and mouse samples. It is commonly used in research to study the expression and function of BMP-8b in various tissues. This antibody is highly specific and shows minimal cross-reactivity with other BMP family members .

The mouse anti-human BMP-8b antibody is widely used in various applications, including Western blotting, immunohistochemistry, and ELISA. It helps researchers investigate the role of BMP-8b in different biological processes and diseases. The antibody is typically purified using antigen affinity purification methods to ensure high specificity and sensitivity .