Leptin PAT7E10AT Antibody

Leptin Clone PAT7E10AT, Mouse Anti Human

Shipped with Ice Packs
Cat. No.
BT3282
Source
Appearance
Sterile filtered colorless solution.

Acrp30 Antibody

Adiponectin, Mouse Anti Human

Shipped with Ice Packs
Cat. No.
BT3358
Source
Appearance
Sterile Filtered solution.

AIMP1 Antibody

Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein 1, Mouse Anti Human

Shipped with Ice Packs
Cat. No.
BT3458
Source
Appearance
Sterile filtered colorless solution.

ANGPTL3 (PAT23D8AT) Antibody

Mouse Anti Human Angiopoietin Like Protein 3 Clone PAT23D8AT

Shipped with Ice Packs
Cat. No.
BT3515
Source
Appearance
Sterile filtered colorless solution.

APOA1 Antibody

Apolipoprotein A-I, Mouse Anti Human

Shipped with Ice Packs
Cat. No.
BT3598
Source
Appearance

BAFF Antibody

B-cell Activating Factor, Mouse Anti Human

Shipped with Ice Packs
Cat. No.
BT3679
Source
Appearance
Sterile Filtered colorless solution.

BD 3 Antibody

Beta Defensin-3, Mouse Anti Human

Shipped with Ice Packs
Cat. No.
BT3743
Source
Appearance

BDNF Antibody

Brain-Derived Neurotrophic Factor, Mouse Anti-Human

Shipped with Ice Packs
Cat. No.
BT3818
Source
Appearance

BMP 2 Antibody

Bone Morphogenetic protein-2, Mouse Anti-Human

Shipped with Ice Packs
Cat. No.
BT3886
Source
The BMP-2 antibody was prepared by affinity chromatography from ascites of BALB/c mouseinoculated by a hybridoma cell that secreted anti- BMP-2 monoclonal antibodies.
Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.

BMP7 Antibody

Bone Morphogenetic Protein-7, Mouse Anti Human

Shipped with Ice Packs
Cat. No.
BT3931
Source
Appearance
Sterile Filtered colorless solution.
Definition and Classification

Anti-human cytokines are antibodies or molecules that specifically target and neutralize human cytokines. Cytokines are small proteins crucial for cell signaling in immune responses. Anti-human cytokines can be classified based on their target cytokines, such as anti-interleukin (IL) antibodies, anti-tumor necrosis factor (TNF) antibodies, and anti-interferon (IFN) antibodies.

Biological Properties

Key Biological Properties: Anti-human cytokines exhibit high specificity and affinity for their target cytokines, effectively neutralizing their biological activity. They are typically monoclonal antibodies produced using hybridoma technology or recombinant DNA technology.

Expression Patterns: These antibodies are not naturally occurring in the body but are produced in laboratories for research and therapeutic purposes.

Tissue Distribution: Once administered, anti-human cytokines distribute throughout the body, targeting tissues where their specific cytokines are expressed.

Biological Functions

Primary Biological Functions: The main function of anti-human cytokines is to inhibit the activity of their target cytokines. This inhibition can modulate immune responses, reduce inflammation, and prevent tissue damage.

Role in Immune Responses: By neutralizing cytokines, these antibodies can downregulate excessive immune responses, which is beneficial in autoimmune diseases and chronic inflammatory conditions.

Pathogen Recognition: While anti-human cytokines do not directly recognize pathogens, they can modulate the immune system’s response to infections by altering cytokine signaling pathways.

Modes of Action

Mechanisms with Other Molecules and Cells: Anti-human cytokines bind to their target cytokines, preventing them from interacting with their receptors on the surface of immune cells. This blockade inhibits downstream signaling pathways that would normally be activated by the cytokines.

Binding Partners: The primary binding partners of anti-human cytokines are the cytokines themselves. By binding to these cytokines, the antibodies prevent them from exerting their biological effects.

Downstream Signaling Cascades: The inhibition of cytokine-receptor interactions by anti-human cytokines leads to the suppression of downstream signaling cascades, such as the JAK-STAT pathway, which is involved in the regulation of immune responses.

Regulatory Mechanisms

Regulatory Mechanisms: The expression and activity of anti-human cytokines are controlled by the production methods used in laboratories. These include transcriptional regulation during the production of monoclonal antibodies and post-translational modifications to enhance their stability and efficacy.

Transcriptional Regulation: During the production of monoclonal antibodies, gene expression is tightly regulated to ensure high yields of functional antibodies.

Post-Translational Modifications: Modifications such as glycosylation can enhance the stability, solubility, and efficacy of anti-human cytokines.

Applications

Biomedical Research: Anti-human cytokines are widely used in research to study cytokine functions, signaling pathways, and their roles in diseases.

Diagnostic Tools: These antibodies can be used in diagnostic assays to detect the presence and levels of specific cytokines in biological samples, aiding in the diagnosis of various conditions.

Therapeutic Strategies: Anti-human cytokines are used as therapeutic agents in the treatment of autoimmune diseases, inflammatory disorders, and certain cancers. Examples include anti-TNF antibodies for rheumatoid arthritis and anti-IL-6 antibodies for cytokine release syndrome.

Role in the Life Cycle

Development: During development, cytokines play crucial roles in cell differentiation, growth, and immune system maturation. Anti-human cytokines can be used to study these processes by selectively inhibiting specific cytokines.

Aging: As the immune system ages, cytokine production and regulation can become dysregulated. Anti-human cytokines can help modulate these changes and potentially mitigate age-related inflammatory conditions.

Disease: In diseases such as autoimmune disorders, chronic inflammation, and cancer, cytokine signaling is often dysregulated. Anti-human cytokines can restore balance to the immune system and improve disease outcomes.

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