BMP7 Antibody
Description
Product Specs
Product Science Overview
Bone Morphogenetic Protein-7 (BMP-7), also known as Osteogenic Protein-1 (OP-1), is a member of the Transforming Growth Factor-beta (TGF-β) superfamily. This protein plays a crucial role in various biological processes, including bone and cartilage development, kidney function, and the regulation of brown adipose tissue .
BMP-7 is a secreted ligand that binds to TGF-β receptors, leading to the recruitment and activation of SMAD family transcription factors. These factors regulate gene expression, influencing processes such as embryogenesis, hematopoiesis, neurogenesis, and skeletal morphogenesis . BMP-7 initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2A. This complex formation at the cell surface leads to the phosphorylation and activation of downstream signaling molecules .
- Bone and Cartilage Development: BMP-7 is essential for skeletal patterning and the formation of bones and cartilage. It induces ectopic bone formation and promotes fracture healing .
- Kidney Function: BMP-7 acts as an early inducer of glomeruli formation, playing a critical role in kidney development and function .
- Adipose Tissue Regulation: BMP-7 has been shown to increase the production of brown fat cells, which are involved in thermogenesis and energy expenditure .
BMP-7 has potential therapeutic applications in various fields:
- Orthopedics: Due to its role in bone formation, BMP-7 is used in treatments for bone fractures and spinal fusions.
- Nephrology: BMP-7’s involvement in kidney development makes it a potential therapeutic target for kidney diseases.
- Obesity: Research suggests that BMP-7 therapy could be developed to combat obesity by promoting the formation of brown fat cells .
Mouse anti-human BMP-7 antibodies are used in research to study the protein’s function and its role in various diseases. These antibodies can help in detecting BMP-7 expression levels, understanding its signaling pathways, and developing targeted therapies.
Recent studies have highlighted BMP-7’s role in cancer immunotherapy. Over-expression of BMP-7 has been linked to resistance to anti-PD1 therapy in preclinical models and patients with disease progression while on immunotherapy. BMP-7 regulates pro-inflammatory responses in the tumor microenvironment by suppressing MAPK14 signaling in macrophages and CD4+ T cells .
