BMP 7 Human, His

Bone Morphogenetic Protein-7 (BMP-7), also known as osteogenic protein-1, is a member of the Transforming Growth Factor-beta (TGF-β) superfamily. This family of proteins plays a crucial role in the transformation of mesenchymal cells into bone and cartilage . BMP-7 is particularly significant due to its ability to induce ectopic bone formation and promote fracture healing in human patients .

BMP-7 is a secreted ligand that binds to various TGF-β receptors, leading to the recruitment and activation of SMAD family transcription factors, which regulate gene expression . The protein is initially synthesized as a preproprotein and is proteolytically processed to generate each subunit of the disulfide-linked homodimer . This homodimer plays a vital role in bone, kidney, and brown adipose tissue development .

Recombinant BMP-7, particularly the human recombinant form with a His tag, is produced using recombinant DNA technology. This form is engineered to include a histidine tag (His tag) to facilitate purification and detection. The His tag allows for easy purification using nickel-affinity chromatography, which is a common method for isolating recombinant proteins.

Recombinant BMP-7 has several clinical applications. It is used to promote bone growth and healing, particularly in cases of bone fractures and spinal fusions . Additionally, BMP-7 has been studied for its potential in treating chronic kidney disease and other conditions involving tissue regeneration .