BDNF Antibody
Description
Product Specs
Product Science Overview
Brain-Derived Neurotrophic Factor (BDNF) is a member of the neurotrophin family of growth factors, which are essential for the development, maintenance, and function of the nervous system. BDNF plays a crucial role in neuronal survival, differentiation, and synaptic plasticity, making it a key player in learning, memory, and higher cognitive functions .
BDNF is a protein that is encoded by the BDNF gene. It is initially synthesized as a precursor protein, proBDNF, which is then cleaved to produce the mature BDNF protein. The mature BDNF protein consists of 247 amino acids and forms a homodimer through disulfide bonds. BDNF binds to two types of receptors on the surface of neurons: the high-affinity receptor TrkB (tropomyosin receptor kinase B) and the low-affinity receptor p75NTR .
BDNF is a critical mediator of neuroplasticity, the brain’s ability to reorganize itself by forming new neural connections. This process is essential for learning, memory, and recovery from brain injuries. BDNF promotes the growth and differentiation of new neurons and synapses, and it enhances the strength of existing synapses .
Mouse anti-human BDNF antibodies are monoclonal antibodies produced by immunizing mice with human BDNF protein. These antibodies are highly specific and are used in various research applications, including Western blotting, immunohistochemistry, immunocytochemistry, enzyme-linked immunosorbent assays (ELISA), and flow cytometry .
- Neurodegenerative Diseases: BDNF levels are often altered in neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease. Mouse anti-human BDNF antibodies are used to study the expression and distribution of BDNF in these conditions .
- Psychiatric Disorders: BDNF is also implicated in psychiatric disorders such as depression, schizophrenia, and bipolar disorder. Research using mouse anti-human BDNF antibodies helps to elucidate the role of BDNF in these disorders and to develop potential therapeutic strategies .
- Neurodevelopmental Disorders: BDNF is essential for normal brain development, and its dysregulation is associated with neurodevelopmental disorders such as autism spectrum disorder and Rett syndrome. Mouse anti-human BDNF antibodies are used to investigate the mechanisms underlying these disorders .
