Growth Factors
Product List
Leptin Mouse, PEG
Pegylated Mouse Leptin Recombinant
Since its enlarged hydrodymanic volume Pegylated Leptin runs on SDS-PAGE as A 48 kDa protein and in gel-filtration on Superdex 200 as over 100 kDa protein.
Pegylated Mouse Leptin half-life in circulation after SC injection was over 20 hours. Mouse Leptin was purified by proprietary chromatographic techniques according to Salomon et al (2006) Protein Expression and Purification 47, 128–136 and then pegylated.
Leptin Ovine
Leptin Ovine Recombinant
The Leptin is purified by proprietary chromatographic techniques.
Leptin Ovine, MTS
Leptin Ovine Recombinant, MTS tag
The Leptin is purified by proprietary chromatographic techniques. The membrane translocating sequence Tag is composed of 10 amino acids Val-Leu-Leu-Pro-Val-Leu-Leu-Ala-Ala-Pro located at the N-terminus.
Leptin Porcine
Leptin Porcine Recombinant
The Leptin is purified by proprietary chromatographic techniques.
Leptin Protein
Leptin Human Recombinant
The Leptin is purified by proprietary chromatographic techniques.
Leptin Pufferfish
Leptin Pufferfish Recombinant
Bioactive Leptin Pufferfish (Takifugu rubripes) Recombinant was prepared according to the sequence published by Kurokawa et al. (2005)Peptides 26, 745-750 in two forms: monomer and covalent dimer. MS analysis revealed molecular masses of 15,291 and 30,585 Da, close to the theoretical values of 15,270 and 30,540 Da. CD spectra revealed high similarity to mammalian leptins. Other details of its preparation will be soon published by Yacobovitz et al (in press), General and Comparative Endocrinology.
The Pufferfish Leptin is purified by proprietary chromatographic techniques.
Leptin qA Human
Leptin Antagonist Quadruple Mutant Human Recombinant
Leptin Antagonist Quadruple Mutant was purified by proprietary chromatographic techniques.
Leptin qA Ovine
Leptin Antagonist Quadruple Mutant Ovine Recombinant
Leptin Antagonist Quadruple Mutant Ovine Recombinant was purified by proprietary chromatographic techniques.
Leptin Rabbit
Leptin Rabbit Recombinant
The Leptin is purified by proprietary chromatographic techniques.
Leptin Rat
Leptin Rat Recombinant
The Leptin is purified by proprietary chromatographic techniques.
Introduction
Key Biological Properties: Leptin is a 16-kDa circulating hormone that acts as a major regulator for food intake and energy homeostasis .
Expression Patterns: Leptin is primarily expressed in white adipose tissue but is also produced in smaller amounts by other tissues such as the stomach, placenta, and mammary gland .
Tissue Distribution: Leptin receptors are widely distributed in the brain, particularly in the hypothalamus, as well as in peripheral tissues including the liver, skeletal muscle, and immune cells .
Primary Biological Functions: Leptin’s main function is to regulate long-term energy balance by inhibiting hunger and controlling energy expenditure . It also plays a role in metabolism, endocrine system regulation, and immune system function .
Role in Immune Responses and Pathogen Recognition: Leptin influences immune responses by modulating the activity of immune cells, including T cells and macrophages . It has been shown to enhance the body’s ability to recognize and respond to pathogens .
Mechanisms with Other Molecules and Cells: Leptin acts via its receptor, LepRb, on specialized neuronal populations in the brain, mainly in the hypothalamus and brainstem .
Binding Partners: Leptin binds to its receptor LepRb, which is expressed by various cell types in the brain and peripheral tissues .
Downstream Signaling Cascades: Upon binding to its receptor, leptin activates several downstream signaling pathways, including the JAK/STAT pathway, MAP kinase, and PI-3 kinase pathways .
Control of Expression and Activity: Leptin expression and protein levels are regulated by multiple factors, including hormones such as insulin, glucocorticoids, and catecholamines .
Transcriptional Regulation: The transcription of the LEP gene is influenced by various metabolic and hormonal signals .
Post-Translational Modifications: Leptin undergoes post-translational modifications that affect its stability and activity .
Biomedical Research: Leptin is extensively studied in the context of obesity, diabetes, and metabolic disorders .
Diagnostic Tools: Leptin levels can be measured to assess metabolic health and diagnose conditions such as leptin deficiency .
Therapeutic Strategies: Leptin replacement therapy is used to treat conditions like congenital leptin deficiency and lipodystrophy .
Development to Aging and Disease: Leptin plays a critical role throughout the life cycle, from fetal development to aging . It influences growth, reproductive function, and immune responses . Dysregulation of leptin levels is associated with various diseases, including obesity, diabetes, and neurodegenerative disorders .
