CD Antigens
Product List
FCGR3B Human
CD16b Human Recombinant
FCGR3B produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 188 amino acids (21-200a.a.) and having a molecular mass of 21.4kDa. (Molecular size on SDS-PAGE will appear at approximately 28-40kDa).
FCGR3B is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
FCGR2A Human
CD32a Human Recombinant
FCGR2A Human, HEK
CD32a Human Recombinant, HEK
FCGR2A Human Recombinant is a single, glycosylated, polypeptide chain (30-218 a.a) containing a total of 195 amino acids, having a molecular mass of 21.6kDa.
FCGR2A is fused to a 6 amino acid His-tag at C-terminus and is purified by proprietary chromatographic techniques.
FCGR2B Human
CD32 Human Recombinant
FCGR3A Human
CD16a Human Recombinant
FCGR3A is fused to a 37 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
FCGR3A Human, HEK
CD16a Human Recombinant, HEK
FCGR3A Human Recombinant produced HEK293 Cells is a single, polypeptide chain containing 197 amino acids (18-208 a.a) and having a molecular mass of 22.6 kDa. FCGR3A is fused to a 6 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
FCGR3A Human, Sf9
CD16a Human Recombinant, Sf9
FCGR3A is fused with a 6 amino acids His tag at C-Terminus and purified by proprietary chromatographic techniques.
Introduction
The Fc fragment of IgG receptor, also known as FcγR, is a protein found on the surface of certain immune cells. It binds to the Fc region of IgG antibodies, facilitating various immune responses. FcγRs are classified into three main groups based on their structure and function: FcγRI (CD64), FcγRII (CD32), and FcγRIII (CD16). Each group has subtypes, such as FcγRIIa, FcγRIIb, and FcγRIIIa .
Key Biological Properties: FcγRs are glycoproteins that play a crucial role in the immune system. They are involved in antibody-dependent cellular cytotoxicity (ADCC), phagocytosis, and the release of inflammatory mediators .
Expression Patterns and Tissue Distribution: FcγRs are expressed on various immune cells, including macrophages, neutrophils, dendritic cells, and natural killer (NK) cells. Their expression can be constitutive or inducible, depending on the cell type and the presence of inflammatory signals .
Primary Biological Functions: FcγRs mediate the clearance of pathogens and infected cells by binding to the Fc region of IgG antibodies. This interaction triggers processes such as phagocytosis, ADCC, and the release of cytokines .
Role in Immune Responses and Pathogen Recognition: FcγRs play a vital role in the immune response by recognizing and binding to immune complexes. This binding activates immune cells to destroy pathogens and infected cells, enhancing the body’s ability to fight infections .
Mechanisms with Other Molecules and Cells: FcγRs interact with IgG antibodies that are bound to antigens. This interaction leads to the cross-linking of FcγRs on the surface of immune cells, triggering intracellular signaling cascades .
Binding Partners and Downstream Signaling Cascades: FcγRs bind to the Fc region of IgG antibodies, leading to the activation of signaling pathways involving immunoreceptor tyrosine-based activation motifs (ITAMs). This activation results in various immune responses, including phagocytosis and cytokine release .
Regulatory Mechanisms Controlling Expression and Activity: The expression and activity of FcγRs are regulated by various factors, including cytokines, transcription factors, and post-translational modifications .
Transcriptional Regulation and Post-Translational Modifications: FcγRs are regulated at the transcriptional level by cytokines and other signaling molecules. Post-translational modifications, such as glycosylation, also play a crucial role in modulating the activity and function of FcγRs .
Biomedical Research: FcγRs are used in research to study immune responses and develop therapeutic antibodies .
Diagnostic Tools: FcγRs are utilized in diagnostic assays to detect immune complexes and study antibody responses .
Therapeutic Strategies: FcγRs are targeted in various therapeutic strategies, including the development of monoclonal antibodies for cancer treatment and autoimmune diseases .
Role Throughout the Life Cycle: FcγRs play a role in immune responses throughout the life cycle, from development to aging. They are involved in the clearance of pathogens, regulation of immune responses, and maintenance of immune homeostasis .
From Development to Aging and Disease: FcγRs are essential for the proper functioning of the immune system during development and aging. Dysregulation of FcγR activity can lead to immune-related diseases, such as autoimmune disorders and chronic inflammation .
