CD Antigens
Product List
CD7 Human
CD7 Human Recombinant
CD7 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
CD7 Human, Sf9
CD7 Human Recombinant, Sf9
CD7 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 164 amino acids (26-180a.a.) and having a molecular mass of 17.5kDa (Molecular size on SDS-PAGE will appear at approximately 18-28kDa). CD7 is expressed with a 6 amino acids His tag at C-Terminus and purified by proprietary chromatographic techniques.
Sf9, Baculovirus cells.
Introduction
CD7, also known as GP40, LEU-9, Tp40, or TP41, is a 40 kDa glycoprotein encoded by the CD7 gene located on chromosome 17 . It belongs to the immunoglobulin superfamily and contains a single extracellular immunoglobulin-like domain, a transmembrane region, and a short cytoplasmic tail . CD7 is primarily expressed on thymocytes and mature T cells .
Key Biological Properties: CD7 is a transmembrane protein that plays a crucial role in immune cell function. It is involved in various signaling pathways essential for immune responses .
Expression Patterns: CD7 is one of the earliest antigens to appear on cells of the T-lymphocyte lineage . It is found on thymocytes, mature T cells, and natural killer (NK) cells .
Tissue Distribution: CD7 is predominantly expressed in lymphoid tissues, including the thymus, spleen, and lymph nodes . It is also present in bone marrow and peripheral blood .
Primary Biological Functions: CD7 facilitates the activation and differentiation of T cells and NK cells . It is involved in the early stages of T cell development within the thymus and plays a role in signaling processes that lead to T cell proliferation and cytokine production .
Role in Immune Responses: CD7 is essential for T-cell interactions and T-cell/B-cell interactions during early lymphoid development . It helps guide T cells and NK cells to sites of infection or inflammation, enhancing the body’s ability to respond to pathogens .
Pathogen Recognition: CD7’s involvement in immune cell migration and adhesion contributes to the formation of the immunological synapse, which is crucial for effective communication between immune cells and antigen-presenting cells (APCs) .
Mechanisms with Other Molecules and Cells: CD7 interacts with other cell surface molecules to transmit activation signals vital for an effective immune response . It is implicated in the regulation of immune cell migration and adhesion .
Binding Partners: CD7 has been shown to interact with phosphatidylinositol 3-kinase (PI3K), which is involved in various signaling pathways .
Downstream Signaling Cascades: CD7’s interaction with PI3K and other signaling molecules leads to the activation of downstream signaling pathways that regulate T cell proliferation, cytokine production, and immune cell migration .
Biomedical Research: CD7 is a valuable target for research in immunology and hematology. It is used to study T cell development, immune responses, and signaling pathways .
Diagnostic Tools: CD7 is a reliable clinical marker for T-cell acute lymphoblastic leukemia (T-ALL) and other T cell malignancies . Abnormal CD7 expression levels can provide insights into disease progression and treatment response .
Therapeutic Strategies: CD7-targeted therapies are being explored for the treatment of T cell malignancies and autoimmune diseases . These therapies aim to selectively target and eliminate malignant cells while sparing normal immune cells .
Development: CD7 is involved in the early stages of T cell development within the thymus . It plays a role in the signaling processes that lead to T cell proliferation and differentiation .
Aging: The expression and function of CD7 may change with age, affecting immune responses and susceptibility to infections and diseases .
Disease: Abnormal CD7 expression is associated with certain leukemias and lymphomas . CD7-targeted therapies and diagnostic tools are being developed to improve disease management and patient outcomes .
