CD Antigens
Product List
CD84 Human
CD84 Human Recombinant
CD84 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
CD84 Human, Sf9
CD84 Human Recombinant, Sf9
CD84 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 213 amino acids (22-225 a.a.) and having a molecular mass of 23.8kDa (Molecular size on SDS-PAGE will appear at approximately 28-40kDa).
CD84 is expressed with a 6 amino acids His tag at C-Terminus and purified by proprietary chromatographic techniques.
Sf9, Baculovirus cells.
Introduction
CD84, also known as SLAMF5 (Signaling Lymphocytic Activation Molecule Family Member 5), is a membrane glycoprotein that belongs to the CD2 subset of the immunoglobulin (Ig) superfamily . It is encoded by the CD84 gene located on chromosome 1q23.3 in humans . CD84 is a homophilic adhesion molecule, meaning it binds to itself on adjacent cells, facilitating cell-cell interactions .
Key Biological Properties: CD84 is involved in various immune processes, including cell adhesion, immune response regulation, and signal transduction .
Expression Patterns and Tissue Distribution: CD84 is predominantly expressed in immune cells such as T cells, B cells, natural killer (NK) cells, and monocytes . It is also found in lymphoid tissues like the spleen, thymus, and lymph nodes . Additionally, CD84 expression has been observed in bone marrow and certain non-lymphoid tissues .
Primary Biological Functions: CD84 plays a crucial role in the regulation of immune responses. It is involved in the activation and differentiation of various immune cells, including T cells, B cells, and NK cells . CD84 enhances the secretion of interferon-gamma (IFN-γ) in lymphocytes and induces platelet stimulation .
Role in Immune Responses and Pathogen Recognition: CD84 is essential for the proper functioning of both innate and adaptive immune responses. It modulates the activation and differentiation of immune cells, thereby contributing to the body’s defense against pathogens .
Mechanisms with Other Molecules and Cells: CD84 interacts with other molecules and cells through homophilic binding, meaning it binds to itself on adjacent cells . This interaction facilitates cell-cell adhesion and communication .
Binding Partners and Downstream Signaling Cascades: CD84 interacts with small cytoplasmic adapter proteins such as SH2D1A (SAP) and SH2D1B (EAT-2), which modulate its signaling pathways . These interactions lead to the activation of downstream signaling cascades, including the PI3K-AKT and MAPK pathways, which are crucial for immune cell activation and function .
Regulatory Mechanisms Controlling Expression and Activity: The expression and activity of CD84 are tightly regulated at multiple levels. Transcriptional regulation involves various transcription factors that bind to the promoter region of the CD84 gene . Post-translational modifications, such as phosphorylation, also play a role in modulating CD84 activity and function .
Biomedical Research: CD84 is a valuable target in biomedical research due to its role in immune regulation. It is studied in the context of autoimmune diseases, infectious diseases, and cancer .
Diagnostic Tools: CD84 expression levels can serve as biomarkers for certain diseases, including chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML) .
Therapeutic Strategies: Targeting CD84 with specific antibodies or small molecules holds potential for therapeutic interventions in diseases where CD84 plays a critical role, such as leukemia and other immune-related disorders .
Role Throughout the Life Cycle: CD84 is involved in various stages of the immune response throughout the life cycle. During development, it contributes to the maturation and differentiation of immune cells . In adulthood, CD84 plays a role in maintaining immune homeostasis and responding to infections . In aging and disease, dysregulation of CD84 expression and function can contribute to immune-related disorders and malignancies .
