CD Antigens
Product List
CD207 Human
CD207 Human Recombinant
CD207 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
CD207 Human, sf9
CD207 Human Recombinant, sf9
Introduction
CD207, also known as Langerin, is a type II transmembrane protein encoded by the CD207 gene in humans. It is a C-type lectin receptor primarily expressed on Langerhans cells (LCs), which are specialized dendritic cells found in the epidermis and mucosal tissues . CD207 is crucial for the formation of Birbeck granules, unique organelles within LCs .
Key Biological Properties: CD207 is a calcium-dependent lectin with mannose-binding specificity. It binds to sulfated and mannosylated glycans, keratan sulfate, and beta-glucans .
Expression Patterns and Tissue Distribution: CD207 is predominantly expressed in Langerhans cells located in the epidermis and mucosal tissues. It is also found in other dendritic cell subsets, including dermal interstitial CD103+ dendritic cells and resident CD8+ dendritic cells in lymph nodes .
Primary Biological Functions: CD207 plays a pivotal role in antigen uptake and processing. It facilitates the internalization of antigens into Birbeck granules, leading to their degradation and presentation to T cells .
Role in Immune Responses and Pathogen Recognition: CD207 is involved in the immune response against various pathogens, including HIV-1, Mycobacterium leprae, and Candida albicans. It recognizes and binds to carbohydrates such as mannose, fucose, and N-acetylglucosamine on the surface of these pathogens .
Mechanisms with Other Molecules and Cells: CD207 interacts with other molecules and cells through its carbohydrate recognition domain (CRD). It forms homotrimers, increasing the avidity and specificity of antigen binding .
Binding Partners and Downstream Signaling Cascades: CD207 binds to high-mannose structures on pathogens, leading to their internalization into Birbeck granules. This process involves endocytosis and subsequent antigen processing for presentation on MHC class I and II molecules .
Regulatory Mechanisms Controlling Expression and Activity: The expression of CD207 is regulated at multiple levels, including transcriptional regulation by factors such as TGF-β1. Post-translational modifications, such as glycosylation, also play a role in its function .
Transcriptional Regulation and Post-Translational Modifications: CD207 expression is influenced by the tissue environment and the maturation state of dendritic cells. Transforming growth factor-beta (TGF-β1) is a key regulator of CD207 expression in Langerhans cells .
Biomedical Research: CD207 is used as a marker for Langerhans cells in research studies. It helps in understanding the biology of dendritic cells and their role in immune responses .
Diagnostic Tools: Antibodies targeting CD207 are used in immunohistochemistry and flow cytometry to identify Langerhans cells in tissue samples .
Therapeutic Strategies: CD207 is being explored as a potential target for immunotherapy, particularly in diseases involving Langerhans cells, such as Langerhans cell histiocytosis .
Role Throughout the Life Cycle: CD207 plays a critical role in the development and function of Langerhans cells from early development to aging. It is involved in the maintenance of immune homeostasis and the response to pathogens throughout life .
From Development to Aging and Disease: The expression and function of CD207 can be altered in various diseases, including Langerhans cell histiocytosis, where pathogenic Langerhans cells proliferate abnormally .
