CD Antigens
Product List
CD93 Human
CD93 Human Recombinant
CD93 is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
CD93 Mouse
CD93 Mouse Recombinant
Introduction
CD93, also known as complement protein 1 q subcomponent receptor (C1qR1 or C1qRp), is a transmembrane glycoprotein encoded by the CD93 gene located on chromosome 20p11.21 in humans . It belongs to the Group XIV C-Type lectin family, which includes other members such as thrombomodulin, CLEC14A, and CD248 .
Key Biological Properties: CD93 is a C-type lectin transmembrane receptor involved in cell-cell adhesion and host defense . It can exist in two forms: soluble (sCD93) and membrane-bound (CD93) .
Expression Patterns: CD93 is primarily expressed on endothelial cells, but it is also found on platelets, monocytes, microglia, and various immune cells such as neutrophils, activated macrophages, B cell precursors, dendritic cells, and natural killer cells .
Tissue Distribution: CD93 is expressed in a wide range of tissues, including the lung, spleen, bone marrow, and various vascular tissues .
Primary Biological Functions: CD93 plays a crucial role in promoting angiogenesis, cell adhesion, and immune regulation . It is involved in endothelial cell dynamics, including cell spreading, migration, and tubular morphogenesis .
Role in Immune Responses: CD93 is involved in immune regulation, including efferocytosis (clearance of apoptotic cells), and plays a role in pathogen recognition . It is also implicated in modulating inflammatory responses .
Mechanisms with Other Molecules and Cells: CD93 interacts with various molecules, including multimerin-2 (MMRN2) and insulin-like growth factor binding protein 7 (IGFBP7), which protect it from proteolytic cleavage . It also interacts with integrin β1, influencing fibronectin fibrillogenesis .
Binding Partners and Downstream Signaling Cascades: CD93’s interaction with VEGFR2 (vascular endothelial growth factor receptor 2) modulates endothelial cell junctions and vascular stability . It also participates in downstream signaling cascades that regulate angiogenesis and immune responses .
Expression and Activity Control: CD93 expression is regulated at both transcriptional and post-transcriptional levels . Tumor-derived factors can alter gene transcription in endothelial cells, affecting CD93 expression .
Transcriptional Regulation: Specific transcription factors and signaling pathways modulate CD93 gene expression in response to various physiological and pathological stimuli .
Post-Translational Modifications: CD93 undergoes post-translational modifications, including glycosylation, which are crucial for its stability and function .
Biomedical Research: CD93 is a valuable biomarker in cancer research due to its role in tumor angiogenesis and immune modulation . It is also studied in the context of cardiovascular diseases and inflammatory disorders .
Diagnostic Tools: CD93 levels can serve as diagnostic markers for various diseases, including cancer and inflammatory conditions .
Therapeutic Strategies: CD93 inhibitors are being explored as potential therapeutic agents for cancer and chronic inflammatory diseases . These inhibitors can disrupt pathological processes by blocking CD93 activity .
Development: CD93 is involved in early embryonic stages, contributing to cell proliferation, migration, and angiogenesis .
Aging and Disease: CD93 expression and function are implicated in age-related diseases such as macular degeneration and cardiovascular diseases . It also plays a role in the progression of inflammatory and neoplastic diseases .
