CD93 Mouse

CD93 is an approximately 125 kDa O-sialoglycoprotein that is highly glycosylated. It is composed of 652 amino acids and can exist in two forms: soluble (sCD93) and membrane-bound (CD93) . The protein is expressed on various cell types, including monocytes, neutrophils, endothelial cells, hematopoietic stem cells, cytotrophoblast cells, platelets, B cells, and natural killer (NK) cells .

CD93 is involved in several critical biological functions:

1. Angiogenesis: CD93 is primarily expressed on endothelial cells, where it promotes angiogenesis. It is highly expressed in tumor-associated vessels and correlates with poor prognosis and high tumor, node, and metastasis (TNM) stage in many cancer types .
2. Inflammation: CD93 modulates inflammatory responses and is involved in diseases such as systemic sclerosis and neuroinflammation .
3. Phagocytosis: CD93 enhances bacterial phagocytosis, clearance of apoptotic cells, and neutralization of viruses .
4. Hematopoiesis: CD93 is a marker for early multipotent hematopoietic precursor cells and plays a role in cell-cell interactions during hematopoietic and vascular development .

Recombinant CD93 proteins are produced using various expression systems, such as HEK293 cells, to study their functions and potential therapeutic applications. These recombinant proteins are often tagged with polyhistidine for purification and detection purposes . Recombinant CD93 has been shown to promote tube formation and sprouting in endothelial cells, accelerating wound healing and promoting the formation of vascular-like structures in mouse subcutaneous tissue .

CD93 is a potential therapeutic target for various diseases due to its involvement in angiogenesis, inflammation, and tumor growth. Researchers are exploring its role in modulating these processes to develop new treatments for conditions such as age-related macular degeneration, cancer, and cardiovascular diseases .