Growth Factors
Product List
Leptin Rat, PEG
Pegylated Rat Leptin Recombinant
Leptin tA Ovine, PEG
Leptin Antagonist Triple Mutant Ovine Recombinant, Pegylated
Pegylated Leptin Antagonist Triple Mutant Ovine Recombinant is a single non-glycosilated polypeptide chain containing 146 aa and an additional Ala at N-terminus and having a molecular mass of ~ 35.6 kDa, Leptin was mutated, resulting in L39A/D40A/F41A mutant. However due to enlarged hydrodymanic volume it runs on the SGS-Page as 48 kDa protein and in gel-filtration on Superdex 200 as over 200kDa protein. Leptin Antagonist Triple Mutant Ovine Recombinant Mono-Pegylated with 20kDa PEG and was purified by proprietary chromatographic techniques.
Leptin tA Rat
Leptin Antagonist Triple Mutant Rat Recombinant
Leptin tA Rat, PEG
Leptin Antagonist Triple Mutant Pegylated Rat Recombinant
The Rat Leptin antagonist was mutated, resulting in L39A/D40A/F41A mutant.
The Rat Leptin antagonist is bound to 20 kDa mono-PEG at N-terminus, resulting in 35.6 kDa. The Rat Leptin triple anatagonist runs as a 48 kDa.
Leptin Antagonist Triple Mutant Rat Recombinant was purified by proprietary chromatographic techniques.
Leptin Receptor Chicken
Leptin Receptor Chicken Recombinant
The Leptin Binding Domain is purified by proprietary chromatographic techniques.
Leptin Salamander
Leptin Salamander Recombinant
Leptin tA Human
Leptin Antagonist Triple Mutant Human Recombinant
Leptin tA Human, PEG
Leptin Antagonist Triple Mutant Human Recombinant, Pegylated
Leptin tA Mouse
Leptin Antagonist Triple Mutant Mouse Recombinant
Leptin tA Mouse, PEG
Leptin Antagonist Triple Mutant Pegylated Mouse Recombinant
The Mouse Leptin antagonist was mutated, resulting in L39A/D40A/F41A mutant.
The Mouse Leptin antagonist is bound to 20 kDa mono-PEG at N-terminus, resulting in 35.6 kDa. The Mouse Leptin triple anatagonist runs as a 48 kDa.
Leptin Antagonist Triple Mutant Mouse Recombinant was purified by proprietary chromatographic techniques.
Introduction
Key Biological Properties: Leptin is a 16-kDa circulating hormone that acts as a major regulator for food intake and energy homeostasis .
Expression Patterns: Leptin is primarily expressed in white adipose tissue but is also produced in smaller amounts by other tissues such as the stomach, placenta, and mammary gland .
Tissue Distribution: Leptin receptors are widely distributed in the brain, particularly in the hypothalamus, as well as in peripheral tissues including the liver, skeletal muscle, and immune cells .
Primary Biological Functions: Leptin’s main function is to regulate long-term energy balance by inhibiting hunger and controlling energy expenditure . It also plays a role in metabolism, endocrine system regulation, and immune system function .
Role in Immune Responses and Pathogen Recognition: Leptin influences immune responses by modulating the activity of immune cells, including T cells and macrophages . It has been shown to enhance the body’s ability to recognize and respond to pathogens .
Mechanisms with Other Molecules and Cells: Leptin acts via its receptor, LepRb, on specialized neuronal populations in the brain, mainly in the hypothalamus and brainstem .
Binding Partners: Leptin binds to its receptor LepRb, which is expressed by various cell types in the brain and peripheral tissues .
Downstream Signaling Cascades: Upon binding to its receptor, leptin activates several downstream signaling pathways, including the JAK/STAT pathway, MAP kinase, and PI-3 kinase pathways .
Control of Expression and Activity: Leptin expression and protein levels are regulated by multiple factors, including hormones such as insulin, glucocorticoids, and catecholamines .
Transcriptional Regulation: The transcription of the LEP gene is influenced by various metabolic and hormonal signals .
Post-Translational Modifications: Leptin undergoes post-translational modifications that affect its stability and activity .
Biomedical Research: Leptin is extensively studied in the context of obesity, diabetes, and metabolic disorders .
Diagnostic Tools: Leptin levels can be measured to assess metabolic health and diagnose conditions such as leptin deficiency .
Therapeutic Strategies: Leptin replacement therapy is used to treat conditions like congenital leptin deficiency and lipodystrophy .
Development to Aging and Disease: Leptin plays a critical role throughout the life cycle, from fetal development to aging . It influences growth, reproductive function, and immune responses . Dysregulation of leptin levels is associated with various diseases, including obesity, diabetes, and neurodegenerative disorders .
