Growth Factors
Product List
GH Zebrafish Mutant
Growth Hormone Mutant Zebrafish Recombinant
GHBP Human
GHBP Human Recombinant
GHBP Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 248 amino acids and having a molecular mass of 28107.01 Dalton.
GHR is purified by proprietary chromatographic techniques.
GHBP Human, His
Growth Hormone Binding Protein Human Recombinant, His Tag
GHBP produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 254 amino acids (19-264a.a.) and having a molecular mass of 29.4kDa.
GHBP is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
GHBP Human, Sf9
Growth Hormone Binding Protein Human Recombinant, Sf9
GHBP Human produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 254 amino acids (19-264aa) and having a molecular mass of 29.4kDa.
GHBP is fused to a 8 amino acid His tag at C-terminus and purified by proprietary chromatographic techniques.
GHBP Ovine
Growth Hormone Binding Protein Ovine Recombinant
GHBP is purified by proprietary chromatographic techniques.
GHBP Rabbit
Growth Hormone Binding Protein Rabbit Recombinant
Growth Hormone Binding Protein Rabbit Extracellular Domain Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 249 amino acids and having a molecular mass of 28 kDa. GHBP Rabbit is purified by proprietary chromatographic techniques.
GHBP Rat
GH Binding Protein Rat Recombinant
GHBP is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
pGH 20kDa Human
Growth Hormone Placental 20kDa Human Recombinant
GH 20K placental is purified by proprietary chromatographic techniques.
pGH 22kDa Human
Growth Hormone Placental 22kDa Human Recombinant
GH Placental Human Recombinant is purified by proprietary chromatographic techniques.
Introduction
Growth hormone (GH), also known as somatotropin or human growth hormone (hGH), is a peptide hormone that stimulates growth, cell reproduction, and cell regeneration in humans and other animals . It is secreted by the anterior lobe of the pituitary gland and plays a crucial role in human development . GH is classified as a mitogen, which is specific to certain types of cells .
Key Biological Properties: GH is a 191-amino acid, single-chain polypeptide . It stimulates protein synthesis, increases fat breakdown, and opposes the action of insulin . GH also stimulates the production of insulin-like growth factor 1 (IGF-1), which mediates many of its growth-promoting effects .
Expression Patterns and Tissue Distribution: GH is synthesized and secreted by somatotropic cells in the anterior pituitary gland . It is released in a pulsatile manner, with surges occurring after the onset of deep sleep . GH receptors are widely distributed in various tissues, including the liver, muscle, and bone .
Primary Biological Functions: GH stimulates the growth of essentially all tissues of the body, including bone . It plays a vital role in normal physical growth in children, with levels peaking during puberty . GH also promotes lipolysis, increases muscle mass, and enhances protein synthesis .
Role in Immune Responses and Pathogen Recognition: GH has been shown to stimulate immune function, although the exact mechanisms are not fully understood . It is believed to enhance the activity of immune cells and promote the production of cytokines .
Mechanisms with Other Molecules and Cells: GH exerts its effects by binding to the growth hormone receptor (GHR) on target cells . This binding activates the JAK-STAT signaling pathway, leading to the transcription of GH-responsive genes . GH also stimulates the production of IGF-1, which acts in an autocrine and paracrine manner to promote growth .
Binding Partners and Downstream Signaling Cascades: GH binds to GHR, which then associates with Janus kinase 2 (JAK2), leading to the phosphorylation of both GHR and JAK2 . This activation triggers downstream signaling cascades, including the MAPK and PI3K/AKT pathways .
Regulatory Mechanisms Controlling Expression and Activity: GH secretion is regulated by the hypothalamic hormones growth hormone-releasing hormone (GHRH) and somatostatin . GHRH stimulates GH release, while somatostatin inhibits it . Additionally, GH secretion is influenced by metabolic factors, such as glucose and lipid levels, and peripheral hormones like insulin .
Transcriptional Regulation and Post-Translational Modifications: GH gene expression is regulated by transcription factors, including Pit-1 . Post-translational modifications, such as phosphorylation, also play a role in modulating GH activity .
Biomedical Research: GH is used in research to study growth disorders and metabolic diseases . It is also employed in experiments to understand its role in cell growth and differentiation .
Diagnostic Tools: GH levels are measured to diagnose growth hormone deficiency (GHD) and acromegaly . GH stimulation tests and IGF-1 measurements are commonly used diagnostic tools .
Therapeutic Strategies: Recombinant human growth hormone (rhGH) is used to treat children with growth disorders and adults with GH deficiency . GH therapy has also been explored for its potential to enhance fertility and improve outcomes in assisted reproductive technologies .
Development: GH is essential for normal growth and development in children . It promotes the growth of bones and tissues, leading to increased height and muscle mass .
Aging and Disease: GH levels decline with age, which is associated with decreased muscle mass and increased fat accumulation . GH therapy has been investigated for its potential to counteract some of the effects of aging . Additionally, GH dysregulation is implicated in various diseases, including acromegaly and growth hormone deficiency .
