Cytokines
Product List
TSLP Human
Thymic Stromal Lymphopoietin Human Recombinant
The TSLP is purified by proprietary chromatographic techniques.
TSLP Human, His
Thymic Stromal Lymphopoietin Human Recombinant, His Tag
TSLP Mouse
Thymic Stromal Lymphopoietin Mouse Recombinant
TSLP Mouse Recombinant produced in Baculovirus is a single glycosylated polypeptide chain containing 130 amino acids (20-140aa) and having a molecular mass of 15.0kDa.
TSLP is fused to a 6 amino acid His-Tag at C-terminus and purified by proprietary chromatographic techniques.
Sf9, Baculovirus cells.
TSLPR Human
Thymic Stromal Lymphopoietin Receptor Human Recombinant
TSLPR is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
TSLPR Human, Sf9
Thymic Stromal Lymphopoietin Receptor Human Recombinant, Sf9
TSLPR is fused to a 6 amino acid His-Tag at C-terminus and purified by proprietary chromatographic techniques.
Introduction
Thymic stromal lymphopoietin (TSLP) is an interleukin (IL)-2-like cytokine, alarmin, and growth factor involved in numerous physiological and pathological processes, primarily those of the immune system . It shares a common ancestor with IL-7 . TSLP is classified as a pleiotropic cytokine due to its ability to exert multiple effects on various cell types .
Key Biological Properties: TSLP is a pleiotropic cytokine that plays a critical role in the development and progression of allergy and asthma . It is primarily produced by epithelial cells and functions as a potent immune system activator .
Expression Patterns: TSLP is primarily expressed by activated lung and intestinal epithelial cells, keratinocytes, and fibroblasts . Dendritic cells (DCs), mast cells, and other immune cells can also produce TSLP .
Tissue Distribution: TSLP is expressed in various tissues, including the lungs, skin, and intestines . It is also found in the pancreatic epithelial cells, gallbladder, cartilage tissue, liver, heart, urinary bladder, prostate, and coronary artery .
Primary Biological Functions: TSLP is involved in the regulation of signaling receptor activity, interleukin-7-mediated signaling pathway, and positive regulation of cytokine-mediated signaling pathways . It also plays a role in the positive regulation of cell population proliferation, chemokine production, and interleukin production .
Role in Immune Responses: TSLP is a key player in the immune response to environmental insults, initiating a number of downstream inflammatory pathways . It activates dendritic cells to promote T helper (Th) 2 immune responses and directly promotes Th2 differentiation of naïve CD4+ T cells .
Pathogen Recognition: TSLP is involved in the defense response to Gram-negative bacteria and fungi .
Mechanisms with Other Molecules and Cells: TSLP exerts its biological effects by binding to a high-affinity heteromeric complex composed of the thymic stromal lymphopoietin receptor (TSLPR) chain and IL-7Rα . This binding leads to the activation of Janus kinase (JAK)1 and 2, which in turn activates signal transducer and activator of transcription (STAT)5A and 5B, and to a lesser extent, STAT1 and 3 .
Binding Partners: TSLP binds to the TSLPR and IL-7Rα receptor complex .
Downstream Signaling Cascades: Upon binding to its receptor complex, TSLP activates JAK1 and 2, leading to the activation of STAT5A and 5B, and to a lesser extent, STAT1 and 3 .
Regulatory Mechanisms: The expression and activity of TSLP are regulated by various transcription factors, including NF-κB and AP-1 . Environmental factors such as Toll-like receptor ligands, viruses, microbes, allergens, and pollutants can trigger TSLP production . Proinflammatory cytokines, Th2-related cytokines, and IgE also induce or enhance TSLP production .
Transcriptional Regulation: TSLP mRNA expression is regulated transcriptionally by NF-κB and AP-1 .
Post-Translational Modifications: TSLP can be cleaved by several endogenous proteases in pathological conditions .
Biomedical Research: TSLP is a critical player in the development and progression of allergy and asthma, making it a valuable target for research .
Diagnostic Tools: TSLP levels can be measured to assess the severity of allergic diseases and asthma .
Therapeutic Strategies: Tezepelumab, a monoclonal antibody targeting TSLP, has been approved for the treatment of severe asthma . Several clinical trials are evaluating the safety and efficacy of tezepelumab in different inflammatory disorders .
Development: TSLP is involved in the proliferation and development of immature B cells . It also promotes Th2 and Treg cells required for a successful pregnancy .
Aging and Disease: TSLP plays a role in chronic inflammatory and autoimmune disorders, such as chronic obstructive pulmonary disease, celiac disease, psoriasis, and rheumatoid arthritis . It is also implicated in certain cancers .
