Cytokines
Product List
EREG Human
Epiregulin Human Recombinant
Epiregulin Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 49 amino acids and having a molecular mass of 5.6 kDa.
Epiregulin is purified by proprietary chromatographic techniques.
EREG Human, HEK
Epiregulin Human Recombinant, HEK
EREG Human Recombinant produced in HEK293 cells is a single, glycosylated polypeptide chain (63-108a.a) containing 289 amino acids and having a molecular mass of 32.6 kDa.
EREG is fused to a 239 amino acid hIgG-His-Tag at C-terminus & purified by proprietary chromatographic techniques.
EREG Human, His
Epiregulin Human Recombinant, His Tag
Introduction
Epiregulin (EPR), encoded by the EREG gene, is a member of the epidermal growth factor (EGF) family . It functions as a ligand for the epidermal growth factor receptor (EGFR) and other members of the ERBB family of tyrosine-kinase receptors . Epiregulin consists of 46 amino acid residues and has a molecular weight of approximately 5280.1 g/mol .
Key Biological Properties: Epiregulin exhibits bifunctional regulatory properties, inhibiting the growth of several epithelial tumor cells while stimulating the growth of fibroblasts and various other cell types .
Expression Patterns and Tissue Distribution: Epiregulin is expressed in various tissues, including the skin, lung, and certain tumor tissues . It is particularly upregulated in conditions such as non-small cell lung cancer (NSCLC) and systemic sclerosis (SSc) .
Primary Biological Functions: Epiregulin plays a crucial role in cellular processes such as cell proliferation, invasion, and angiogenesis . It acts as an autocrine growth factor in normal human keratinocytes, stimulating their proliferation .
Role in Immune Responses and Pathogen Recognition: Epiregulin is involved in immune responses, particularly in the activation and transdifferentiation of fibroblasts to myofibroblasts in autoimmune diseases like systemic sclerosis .
Mechanisms with Other Molecules and Cells: Epiregulin binds to EGFR and ErbB4, stimulating downstream signaling pathways . It exhibits bifunctional regulatory properties by inhibiting the growth of epithelial tumor cells and stimulating the growth of fibroblasts .
Binding Partners and Downstream Signaling Cascades: Epiregulin interacts with EGFR and other ERBB family receptors, leading to the activation of various downstream signaling cascades involved in cell proliferation and survival .
Regulatory Mechanisms Controlling Expression and Activity: Epiregulin expression is regulated at both the transcriptional and post-translational levels. Transcriptional regulation involves various growth factors such as EGF, HB-EGF, amphiregulin, and TGF-α, which upregulate epiregulin mRNA levels .
Post-Translational Modifications: Epiregulin undergoes post-translational modifications that influence its activity and stability .
Biomedical Research: Epiregulin is used in research to understand its role in cellular processes and disease mechanisms, particularly in cancer and autoimmune diseases .
Diagnostic Tools: Elevated levels of epiregulin can serve as a biomarker for certain cancers and autoimmune diseases .
Therapeutic Strategies: Targeting epiregulin and its signaling pathways holds potential for developing new therapeutic strategies for diseases such as non-small cell lung cancer and systemic sclerosis .
