Neurotrophins
Product List
CNTF Human
Ciliary-Neurotrophic Factor Human Recombinant
The CNTF is purified by proprietary chromatographic techniques.
CNTF Human, His
Ciliary Neurotrophic Factor Human Recombinant, His Tag
CNTF Human, His Active
Ciliary Neurotrophic Factor Human Recombinant, His Tag Active
CNTF is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
CNTF Mouse
Ciliary-Neurotrophic Factor Mouse Recombinant
The CNTF is purified by proprietary chromatographic techniques.
CNTF Rat
Ciliary Neurotrophic Factor Rat Recombinant
The CNTF is purified by proprietary chromatographic techniques.
CNTF Rat, His
Ciliary Neurotrophic Factor Rat Recombinant, His Tag
CNTF is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
CNTFR Human
Ciliary Neurotrophic Factor Receptor Human Recombinant
CNTFR Rat
Ciliary Neurotrophic Factor Receptor Rat Recombinant
CTNFR Human, Sf9
Ciliary Neurotrophic Factor Receptor Human Recombinant, Sf9
CTNFR produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 329 amino acids (23-342a.a.) and having a molecular mass of 36.9kDa. (Molecular size on SDS-PAGE will appear at approximately 40-57kDa).
CTNFR is expressed with a 9 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
Sf9, Baculovirus cells.
Introduction
Key Biological Properties: CNTF is a potent survival factor for neurons and oligodendrocytes. It promotes neurotransmitter synthesis and neurite outgrowth in certain neural populations, including astrocytes .
Expression Patterns: CNTF is expressed in various tissues, including the hypothalamus, testicles, tibial nerve, sural nerve, gastrocnemius muscle, substantia nigra, and bone marrow .
Tissue Distribution: The expression of CNTF is prominent in the nervous system, particularly in the hypothalamus, where it plays a crucial role in neuronal survival and function .
Primary Biological Functions: CNTF supports the survival and differentiation of various neuronal populations. It is involved in promoting the survival of motor neurons, sensory neurons, and astrocytes .
Role in Immune Responses and Pathogen Recognition: While CNTF’s primary functions are in the nervous system, it also has roles in immune responses, particularly in reducing tissue destruction during inflammatory attacks .
Mechanisms with Other Molecules and Cells: CNTF exerts its effects by binding to a receptor complex consisting of CNTFRα (CNTF receptor alpha), LIFRβ (leukemia inhibitory factor receptor beta), and gp130 (glycoprotein 130) .
Binding Partners: The binding of CNTF to its receptor complex triggers the activation of intracellular signaling pathways, including the JAK/STAT pathway, which is crucial for neuronal survival and differentiation .
Downstream Signaling Cascades: Upon binding to its receptor, CNTF activates the JAK/STAT, MAPK/ERK, and PI3K/Akt pathways, which regulate various cellular mechanisms such as metabolism, apoptosis inhibition, and cytoskeletal dynamics .
Transcriptional Regulation: The expression of CNTF is regulated at the transcriptional level by various factors, including stress stimuli and injury responses .
Post-Translational Modifications: CNTF undergoes post-translational modifications that influence its stability and activity. These modifications include phosphorylation and glycosylation, which are essential for its proper function .
Biomedical Research: CNTF is widely used in research to study neuronal survival, differentiation, and neuroprotection .
Diagnostic Tools: CNTF levels in biological materials, such as blood and tears, are being investigated as potential biomarkers for neurodegenerative and brain diseases .
Therapeutic Strategies: CNTF and its agonists have shown promise in treating neurodegenerative diseases like amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS), as well as retinal degenerative diseases .
Development: CNTF plays a critical role in the development of the nervous system by promoting the survival and differentiation of neurons and glial cells .
Aging and Disease: CNTF continues to be important throughout life, contributing to neuronal maintenance and repair. It has potential therapeutic applications in age-related neurodegenerative diseases and conditions involving neuronal damage .
