Neurotrophins
Product List
MANF Human
Mesencephalic Astrocyte-Derived Neurotrophic Factor Human Recombinant
The MANF is purified by proprietary chromatographic techniques.
MANF Human, His
Mesencephalic Astrocyte-Derived Neurotrophic Factor Human Recombinant, His Tag
MANF is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
MANF Mouse
Mesencephalic Astrocyte-Derived Neurotrophic Factor Mouse Recombinant
MANF Rat
Mesencephalic Astrocyte-Derived Neurotrophic Factor Rat Recombinant
Introduction
Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) is a protein encoded by the MANF gene. It is a member of the neurotrophic factors family, which are proteins that support the growth, survival, and differentiation of neurons. MANF is unique compared to other neurotrophic factors due to its structure and functions .
Key Biological Properties: MANF is an endoplasmic reticulum (ER) stress-inducible protein that plays a crucial role in maintaining ER homeostasis and protecting cells from ER stress-induced apoptosis .
Expression Patterns: MANF is broadly expressed in both developing and mature tissues, including the central nervous system (CNS) and peripheral nervous system (PNS) tissues .
Tissue Distribution: High levels of MANF are found in the cerebral cortex, hippocampus, and cerebellar Purkinje cells. It is also present in non-neuronal tissues .
Primary Biological Functions: MANF promotes the survival of dopaminergic neurons, modulates GABAergic transmission, and inhibits cell proliferation and ER stress-induced cell death .
Role in Immune Responses and Pathogen Recognition: MANF has been shown to protect against amyloid β-peptide (Aβ) toxicity by attenuating ER stress, suggesting its role in immune responses and pathogen recognition in neurodegenerative diseases like Alzheimer’s .
Mechanisms with Other Molecules and Cells: MANF interacts with the ER chaperone protein HSPA5 under normal conditions and is upregulated and secreted in response to ER stress and hypoxia .
Binding Partners and Downstream Signaling Cascades: MANF activates Akt/mTOR and Erk/mTOR signaling pathways, which are crucial for neurite outgrowth and cell survival .
Biomedical Research: MANF is being studied for its neuroprotective effects in various neurological disorders, including Parkinson’s disease, Alzheimer’s disease, and stroke .
Diagnostic Tools: MANF levels can serve as biomarkers for ER stress-related diseases .
Therapeutic Strategies: MANF has potential therapeutic applications in treating neurodegenerative diseases and metabolic disorders .
