Neurotrophins
Product List
NRN1 Human
Neuritin-1 Human Recombinant
The NRN1 is purified by proprietary chromatographic techniques.
NRN1 Human, His
Neuritin-1 Human Recombinant, His Tag
Introduction
Neuritin, also known as candidate plasticity gene 15 (cpg15), is a neurotrophic factor that promotes neurite outgrowth and branching. It is an activity-induced glycosylphosphatidylinositol-anchored axonal protein primarily expressed in the brain . Neuritin belongs to the broader family of growth-promoting factors involved in neuronal plasticity and regeneration .
Key Biological Properties: Neuritin is activated by neural activity and neurotrophins, promoting neurite growth and branching . It plays a crucial role in neuronal plasticity and regeneration .
Expression Patterns: Neuritin mRNA is predominantly expressed in the nervous system, although minor expression can also be detected in other organs . It is modulated by neurotrophic factors, synaptic activity, hormones, sensory experience, and electroconvulsive seizure therapy .
Tissue Distribution: Neuritin is mainly expressed in the brain, particularly in regions associated with synaptic plasticity and neuronal growth .
Primary Biological Functions: Neuritin promotes neurite outgrowth, modulates neurite outgrowth during neuronal differentiation, protects motor neuron axons, promotes dendritic growth, shapes dendritic arbors of target neurons, regulates synaptic plasticity, stabilizes active synapses, promotes synaptic maturation and neuronal migration, and regenerates peripheral nerve and spinal axons .
Role in Immune Responses and Pathogen Recognition: Neuritin has been shown to maintain and promote regulatory T cell (Treg) function in autoimmune diseases and cancer, highlighting its role as an immunoregulatory molecule .
Mechanisms with Other Molecules and Cells: Neuritin interacts with various molecules and cells to exert its effects. It is involved in several signaling pathways, including the MEK-ERK pathway, PI3K-Akt-mTOR pathway, and Ca2±CaN-NFATc4 pathway .
Binding Partners and Downstream Signaling Cascades: Neuritin’s primary mechanisms, including whether it acts through a receptor or which downstream signals might be activated following binding, are not fully understood . However, it has been shown to inhibit Notch signaling through interaction with NEURL1, promoting neurite growth .
Transcriptional Regulation: Neuritin mRNA expression is modulated by neurotrophic factors, synaptic activity, hormones, sensory experience, and electroconvulsive seizure therapy .
Post-Translational Modifications: Neuritin undergoes various post-translational modifications that regulate its activity and function .
Biomedical Research: Neuritin is a potential therapeutic target in several neurodegenerative diseases due to its role in neuronal plasticity and regeneration . It is also being studied for its role in angiogenesis, tumorigenesis, and immunomodulation .
Diagnostic Tools and Therapeutic Strategies: Neuritin’s involvement in various biological processes makes it a promising candidate for developing diagnostic tools and therapeutic strategies for neurodegenerative diseases, cancer, and autoimmune diseases .
Development to Aging and Disease: Neuritin plays a critical role throughout the life cycle, from development to aging and disease. It promotes the development and maturation of visual cortical neurons, regulates apoptosis of proliferative neurons, and regenerates peripheral nerve and spinal axons . Its expression and function are crucial for maintaining neuronal health and function throughout life .
