Neurotrophins
Product List
b NGF Human
Beta Nerve Growth Factor Human Recombinant
The NGF-b is purified by proprietary chromatographic techniques.
b NGF Human, HEK
beta Nerve Growth Factor Human Recombinant, HEK
BNGF Human Recombinant produced in HEK293 is a noncovalently disulfide linked homodimer, glycosylated, polypeptide chain (Ser122-Arg239) containing 2 identical 118 amino acids and having a molecular mass of 26.5 kDa.
HEK293 cells.
b NGF Mouse
Beta-Nerve Growth Factor Mouse
The NGF beta Mouse is purified by advanced biology purification technology.
Beta NGF Mouse
Beta Nerve Growth Factor Mouse Recombinant
The Recombinant Mouse-beta-NGF is purified by advanced biology purification technology.
bNGF Human, CHO
Beta-Nerve Growth Factor Human Recombinant, CHO
The NGF-b is purified by proprietary chromatographic techniques.
NGFR Human
Nerve Growth Factor Receptor Human Recombinant
ProNGF Human
Pro-Nerve Growth Factor Human Recombinant
Pro-NGF Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 224 amino acids and having a molecular mass of 25 kDa.
ProNGF Human Recombinant is purified by proprietary chromatographic techniques.
Introduction
Beta-Nerve Growth Factor (Beta-NGF) is a neurotrophic factor and neuropeptide primarily involved in the regulation of growth, maintenance, proliferation, and survival of certain target neurons. It is a member of the neurotrophin family, which also includes Brain-Derived Neurotrophic Factor (BDNF), Neurotrophin-3 (NT-3), and Neurotrophin-4 (NT-4). Beta-NGF is the biologically active component of the 7S NGF complex, which also includes Alpha-NGF and Gamma-NGF .
Key Biological Properties: Beta-NGF is crucial for the development and survival of nerve cells (neurons), especially those that transmit pain, temperature, and touch sensations. It functions by attaching to its receptors, initiating signaling pathways inside the cell .
Expression Patterns: Beta-NGF is expressed in various tissues, including the central and peripheral nervous systems, as well as non-neuronal tissues such as the immune system .
Tissue Distribution: It is produced by every peripheral tissue/organ innervated by sensory afferents and/or sympathetic efferents, as well as by central and peripheral nervous system and immune cells .
Primary Biological Functions: Beta-NGF promotes the growth, differentiation, and survival of neurons. It is essential for the maintenance of sympathetic and sensory neurons and plays a critical role in the survival of pancreatic beta cells .
Role in Immune Responses: Beta-NGF acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival .
Pathogen Recognition: Beta-NGF is involved in the regulation of the immune system, influencing both innate and adaptive immune responses .
Mechanisms with Other Molecules and Cells: Beta-NGF binds to its high-affinity receptor, Tropomyosin receptor kinase A (TrkA), and low-affinity receptor, p75 neurotrophin receptor (p75NTR). This binding initiates various signaling pathways, including the PI 3-kinase, ras, and PLC pathways .
Binding Partners: The primary binding partners of Beta-NGF are TrkA and p75NTR receptors .
Downstream Signaling Cascades: Upon binding to TrkA, Beta-NGF drives the homodimerization of the receptor, leading to the autophosphorylation of the tyrosine kinase segment and activation of downstream signaling pathways .
Expression and Activity Control: The expression of Beta-NGF is regulated by various factors, including inflammatory cytokines and stress. Its activity is modulated through binding to its receptors and subsequent activation of signaling pathways .
Transcriptional Regulation: The transcription of the NGF gene is influenced by various transcription factors and signaling molecules .
Post-Translational Modifications: Beta-NGF undergoes proteolytic cleavage from its precursor form, proNGF, to become biologically active .
Biomedical Research: Beta-NGF is widely used in research to study neuronal growth, differentiation, and survival. It is also used to investigate the mechanisms of neurodegenerative diseases and potential therapeutic strategies .
Diagnostic Tools: Beta-NGF levels are measured in various diagnostic assays to assess nerve damage and neurodegenerative conditions .
Therapeutic Strategies: Beta-NGF has potential therapeutic applications in treating neurodegenerative diseases, peripheral neuropathies, and certain immune disorders .
Development: Beta-NGF is essential for the development of the nervous system, promoting the growth and differentiation of neurons during embryonic development .
Aging: In adulthood, Beta-NGF maintains the function and survival of neurons, playing a role in cognitive function and memory .
Disease: Beta-NGF is involved in the pathophysiology of various diseases, including neurodegenerative disorders, diabetes, and cancer. It has both neuroprotective and pro-apoptotic roles depending on the context .
