b NGF Mouse
(b) Analysis by SDS-PAGE .
Description
The NGF beta Mouse is purified by advanced biology purification technology.
Product Specs
Product Science Overview
Beta-Nerve Growth Factor (Beta-NGF) is a crucial protein involved in the growth, maintenance, and survival of certain neurons. It is a member of the neurotrophin family, which plays a significant role in the development and function of the nervous system. Beta-NGF is particularly important for the differentiation and survival of sympathetic and sensory neurons.
The discovery of Nerve Growth Factor (NGF) dates back to the 1950s when Rita Levi-Montalcini and Stanley Cohen identified it while studying the effects of a mouse sarcoma on chick embryos . NGF consists of three subunits: alpha, beta, and gamma. The beta subunit, also known as Beta-NGF, is solely responsible for the nerve growth-stimulating activity of NGF . The Beta-NGF protein in mice is composed of two identical 118-amino acid beta-chains, forming a 7S, 130,000-Da complex .
Beta-NGF plays a pivotal role in the regulation of growth and differentiation of sympathetic and certain sensory neurons . It stimulates the division and differentiation of these neurons during development and maintains their function in adulthood. Beta-NGF achieves this by binding to specific receptors on the surface of target neurons, initiating a cascade of intracellular events that promote neuronal survival and growth .
The physiological role of Beta-NGF extends beyond the nervous system. It has been implicated in various clinical conditions, including neurodegenerative diseases, peripheral neuropathies, and certain types of cancer . Research has shown that Beta-NGF can promote the survival and functional activity of peripheral sensory and sympathetic nerve cells, making it a potential therapeutic target for conditions like Alzheimer’s disease and diabetic neuropathy .
Recent studies have explored the potential clinical applications of Beta-NGF. For instance, it has been investigated for its role in promoting nerve regeneration and preventing neuronal degeneration in various animal models . Additionally, Beta-NGF has been studied for its potential use in treating ocular and skin diseases, traumatic brain injuries, and immune disorders .
