NRN1 Human
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.
Description
The NRN1 is purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
The NRN1 gene is located on chromosome 6 and encodes a protein that is expressed in postmitotic-differentiating neurons. This protein is particularly associated with neuronal structures involved in plasticity in the adult nervous system . The expression of NRN1 can be induced by neural activity and neurotrophins, which are proteins that promote the survival, development, and function of neurons .
The Neuritin-1 protein contains a consensus cleavage signal found in glycosylphosphatidylinositol (GPI)-anchored proteins. This signal is essential for the protein’s attachment to the cell membrane, which is crucial for its function in promoting neurite outgrowth and arborization .
Neuritin-1 is known to promote neurite outgrowth and branching of neuritic processes, particularly in primary hippocampal and cortical cells . This function is vital for the formation and maintenance of neural networks, which are essential for learning, memory, and overall brain function.
The protein’s role in promoting neuritogenesis (the process of forming new neurites) suggests its importance in neural development and repair. Studies have shown that Neuritin-1 is upregulated in injured nerves, indicating its involvement in nerve repair and regeneration .
Recombinant Neuritin-1 is produced using an E. coli expression system. The recombinant protein is typically purified to a high degree of purity and is used in various research applications to study its function and potential therapeutic uses . The recombinant form of Neuritin-1 retains the biological activity of the native protein, making it a valuable tool for studying neural development and plasticity.
Overexpression of Neuritin-1 has been associated with the progression of astrocytoma, a type of brain tumor . This suggests that while Neuritin-1 plays a beneficial role in neural development and repair, its dysregulation can contribute to pathological conditions.
Research into Neuritin-1 continues to explore its potential therapeutic applications, particularly in the context of neurodegenerative diseases and nerve injury. By understanding the mechanisms through which Neuritin-1 promotes neurite outgrowth and neural plasticity, scientists hope to develop new treatments for conditions that affect the nervous system.
