CTNFR Human, Sf9

Ciliary Neurotrophic Factor Receptor Human Recombinant, Sf9
Cat. No.
BT8175
Source

Sf9, Baculovirus cells.

Synonyms

Ciliary Neurotrophic Factor Receptor, CNTF Receptor Subunit Alpha, CNTFR-Alpha, Ciliary Neurotrophic Factor Receptor Subunit Alpha.

Appearance
Sterile Filtered colorless clear solution.
Purity

Greater than 95.0% as determined by SDS-PAGE.

Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Shipped with Ice Packs
In Stock
Quick Inquiry

Description

CTNFR produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 329 amino acids (23-342a.a.) and having a molecular mass of 36.9kDa. (Molecular size on SDS-PAGE will appear at approximately 40-57kDa).
CTNFR is expressed with a 9 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

Product Specs

Introduction
Ciliary Neurotrophic Factor Receptor (CNTFR) belongs to the type I cytokine receptor family and plays a crucial role in binding to Ciliary Neurotrophic Factor (CNTF). The alpha subunit of CNTFR determines its receptor specificity. Single nucleotide polymorphisms within the CNTFR gene have been linked to variations in muscle strength and a potential connection to the early onset of eating disorders.
Description
Produced in Sf9 Baculovirus cells, CTNFR is a single, glycosylated polypeptide chain consisting of 329 amino acids (23-342a.a.) with a molecular mass of 36.9kDa. Note that the molecular size on SDS-PAGE analysis will appear approximately between 40-57kDa. CTNFR is expressed with a 9 amino acid His tag at the C-terminus and undergoes purification using proprietary chromatographic techniques.
Physical Appearance
The product is a sterile-filtered solution that is colorless and clear.
Formulation
The CTNFR protein solution is provided at a concentration of 1mg/ml and contains 10% glycerol and Phosphate Buffered Saline (pH 7.4).
Stability
For short-term storage (2-4 weeks), the product should be stored at 4°C. For longer storage periods, freezing at -20°C is recommended. The addition of a carrier protein (0.1% HSA or BSA) is advisable for long-term storage. Avoid repeated freeze-thaw cycles.
Purity
The purity of CTNFR is greater than 95.0% as determined by SDS-PAGE analysis.
Synonyms

Ciliary Neurotrophic Factor Receptor, CNTF Receptor Subunit Alpha, CNTFR-Alpha, Ciliary Neurotrophic Factor Receptor Subunit Alpha.

Source

Sf9, Baculovirus cells.

Amino Acid Sequence

ADPQRHSPQE APHVQYERLG SDVTLPCGTA NWDAAVTWRV NGTDLAPDLL NGSQLVLHGL ELGHSGLYAC FHRDSWHLRH QVLLHVGLPPREPVLSCRSN TYPKGFYCSW HLPTPTYIPN TFNVTVLHGS KIMVCEKDPA LKNRCHIRYM HLFSTIKYKV SISVSNALGH NATAITFDEF TIVKPDPPEN VVARPVPSNP RRLEVTWQTP STWPDPESFP LKFFLRYRPL ILDQWQHVEL SDGTAHTITD AYAGKEYIIQ VAAKDNEIGTWSDWSVAAHA TPWTEEPRHL TTEAQAAETT TSTTSSLAPP PTTKICDPGE LGSHHHHHH.

Product Science Overview

Introduction

The Ciliary Neurotrophic Factor Receptor (CNTFR) is a crucial component in the nervous system, playing a significant role in neuronal cell survival, differentiation, and gene expression . This receptor is part of the type 1 cytokine receptor family and is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor (CNTF) .

Structure and Function

CNTFR is composed of an alpha subunit that provides receptor specificity . When CNTF binds to CNTFR, it recruits the transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal transduction . This interaction is vital for the receptor’s role in promoting neurotransmitter synthesis and neurite outgrowth in certain neural populations, including astrocytes .

Recombinant CNTFR

The recombinant version of human CNTFR, produced in Sf9 insect cells, is designed to mimic the natural receptor’s function. This recombinant protein is used in various research applications to study its role in neuronal survival and differentiation .

Clinical Significance

Mutations in the CNTFR gene have been associated with variations in muscle strength and early onset of eating disorders . Additionally, CNTFR has been implicated in several pathways related to immune system signaling and interleukin-6 family signaling . Understanding the function and structure of CNTFR can provide insights into potential therapeutic targets for neurodegenerative diseases and other conditions affecting the nervous system.

Quick Inquiry

Personal Email Detected
Please use an institutional or corporate email address for inquiries. Personal email accounts ( such as Gmail, Yahoo, and Outlook) are not accepted. *

Category

Service

Related Products

CNTFR Human
Ciliary Neurotrophic Factor Receptor Human Recombinant
Cat. No.
BT8043
Source
Escherichia Coli.
CNTFR Rat
Ciliary Neurotrophic Factor Receptor Rat Recombinant
Cat. No.
BT8109
Source
Sf9, Baculovirus cells.
THE BIOTEK
THE BioTek is a global biotech company offering highly purified proteins for research in cancer, apoptosis, development, endocrinology, immunology, neuroscience, proteases, and stem cells.
  • Contact
  • Address: 1925 E Maple Ave, El Segundo, CA 90245 United States
  • Phone : +1 201-285-7826
  • Email : info@thebiotek.com
  • Hours : Mon.-Fri. 9:00 AM - 5:00 PM
© Copyright 2024 Thebiotek. All Rights Reserved.