CNTFR Human
Ciliary Neurotrophic Factor Receptor Human Recombinant
Cat. No.
BT8043
Source
Escherichia Coli.
Synonyms
Ciliary
Neurotrophic Factor Receptor, CNTF Receptor Subunit Alpha, CNTFR-Alpha, Ciliary
Neurotrophic Factor Receptor Subunit Alpha, Ciliary neurotrophic factor
receptor subunit alpha, CNTF receptor subunit alpha, CNTFR-alpha.
Appearance
Sterile Filtered colorless clear solution.
Purity
Greater than 85.0% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Shipped with Ice Packs 
In Stock 
Description
CNTFR Human Recombinant produced in E.Coli is a single,
non-glycosylated polypeptide chain containing 341 amino acids (23-342 a.a) and
having a molecular mass of 38.1kDa.
CNTFR is fused to a 21 amino acid His-tag at N-terminus
& purified by proprietary chromatographic techniques.
Product Specs
Introduction
Ciliary Neurotrophic Factor Receptor, also known as CNTFR, is a member of the type I cytokine receptor family. CNTFR binds to CNTF. The alpha subunit provides the receptor specificity. Single nucleotide polymorphisms in CNTFR have been associated with variations in muscle strength, in addition to the early onset of eating disorders.
Description
Recombinant human CNTFR, expressed in E. coli, is a single, non-glycosylated polypeptide chain containing 341 amino acids (residues 23-342). It has a molecular weight of 38.1 kDa. The protein is fused to a 21 amino acid His-tag at the N-terminus and purified using proprietary chromatographic techniques.
Physical Appearance
A clear, colorless, and sterile-filtered solution.
Formulation
The CNTFR protein solution is provided at a concentration of 1 mg/ml in a buffer containing 20 mM Tris-HCl (pH 8.0) and 10% glycerol.
Stability
For short-term storage (2-4 weeks), the product can be stored at 4°C. For extended storage, it is recommended to store the product frozen at -20°C. Adding a carrier protein such as 0.1% HSA or BSA is recommended for long-term storage. Avoid repeated freeze-thaw cycles.
Purity
The purity of the protein is greater than 85.0% as determined by SDS-PAGE analysis.
Synonyms
Ciliary
Neurotrophic Factor Receptor, CNTF Receptor Subunit Alpha, CNTFR-Alpha, Ciliary
Neurotrophic Factor Receptor Subunit Alpha, Ciliary neurotrophic factor
receptor subunit alpha, CNTF receptor subunit alpha, CNTFR-alpha.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MQRHSPQEAP HVQYERLGSD VTLPCGTANW DAAVTWRVNG TDLAPDLLNG SQLVLHGLEL
GHSGLYACFH RDSWHLRHQV LLHVGLPPRE PVLSCRSNTY PKGFYCSWHL PTPTYIPNTF NVTVLHGSKI
MVCEKDPALK NRCHIRYMHL FSTIKYKVSI SVSNALGHNA TAITFDEFTI VKPDPPENVV ARPVPSNPRR
LEVTWQTPST WPDPESFPLK FFLRYRPLIL DQWQHVELSD GTAHTITDAY AGKEYIIQVA AKDNEIGTWS
DWSVAAHATP WTEEPRHLTT EAQAAETTTS TTSSLAPPPT TKICDPGELG S.
Product Science Overview
Introduction
Ciliary Neurotrophic Factor (CNTF) is a polypeptide hormone and neurotrophic factor primarily studied for its role in the nervous system. It promotes neurotransmitter synthesis and neurite outgrowth in specific neural populations, including astrocytes . CNTF is a potent survival factor for neurons and oligodendrocytes, potentially reducing tissue destruction during inflammatory attacks .
Discovery and Structure
CNTF was initially identified as a trophic factor for embryonic chick ciliary parasympathetic neurons in culture . The human CNTF gene is located on chromosome 11q12.1 . Recombinant human CNTF (rhCNTF), also known as Axokine, is a modified version with a 15 amino acid truncation of the C-terminus and two amino acid substitutions, making it more potent and stable than the native CNTF .
Biological Functions
Therapeutic Applications
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