Viral Antigens
Product List
Chlamydia HSP70 (462-503 a.a.)
Chlamydia Trachomatis HSP70 (462-503 a.a.) Recombinant
Chlamydia HSP70 (549-660a.a.)
Chlamydia Trachomatis HSP70 (549-660 a.a.) Recombinant
Chlamydia PGP-3D
Chlamidia Trachomatis PGP-3D Recombinant
Chlamydia Pneumonia
Chlamydia Pneumonia Recombinant
Chlamydia W2
Chlamydia Trachomatis W2 Recombinant
The E.coli derived recombinant 6x His fusion at C-terminus protein contains Chlamydia Trachomatis MOMP protein epitopes, 66-165 amino acids.
Chlamydia W3-W6
Chlamidia Trachomatis W3-W6 Recombinant
Chlamydia W4
Chlamydia Trachomatis W4 Recombinant
The E.coli derived recombinant 6xHis fusion at C-terminus protein contains Chlamydia Trachomatis MOMP protein epitopes, 191-286 amino acids.
Chlamydia W4-W5
Chlamydia Trachomatis W4-W5 Recombinant
The E.coli derived recombinant 6xHis fusion at C-terminus protein contains Chlamydia Trachomatis MOMP protein epitopes, 191-354 amino acids.
Chlamydia W5
Chlamydia Trachomatis W5 Recombinant
The E.coli derived recombinant 6x His fusion at C-terminus protein contains Chlamydia Trachomatis MOMP protein epitopes, 252-354 amino acids, and a 6xHis Tag fused at C-terminus.
Chlamydia W5-W6
Chlamydia Trachomatis W5-W6 Recombinant
The E.coli derived recombinant 6xHis fusion at C-terminus protein contains Chlamydia Trachomatis MOMP protein epitopes, 252-398 amino acids.
Introduction
Chlamydia is a genus of pathogenic Gram-negative bacteria that are obligate intracellular parasites. The most well-known species within this genus is Chlamydia trachomatis, which is the leading cause of bacterial sexually transmitted infections (STIs) and infectious blindness worldwide . Chlamydia trachomatis is classified under the order Chlamydiales and the family Chlamydiaceae .
Chlamydia trachomatis exhibits several key biological properties:
- Obligate Intracellular Nature: Chlamydia trachomatis can only replicate within host cells .
- Biphasic Developmental Cycle: It alternates between two forms: the infectious elementary body (EB) and the replicative reticulate body (RB) .
- Expression Patterns and Tissue Distribution: Chlamydia trachomatis primarily infects epithelial cells of the genital tract, respiratory tract, and conjunctiva .
Chlamydia trachomatis plays several critical roles in biological functions:
- Primary Biological Functions: It is responsible for causing various diseases, including trachoma, lymphogranuloma venereum, and pelvic inflammatory disease .
- Role in Immune Responses: Chlamydia trachomatis can modulate host immune responses to evade detection and destruction .
- Pathogen Recognition: The bacteria use specific surface proteins to recognize and bind to host cells .
Chlamydia trachomatis interacts with host cells through several mechanisms:
The expression and activity of Chlamydia trachomatis are controlled by various regulatory mechanisms:
- Transcriptional Regulation: The bacteria’s genome encodes transcription factors that regulate gene expression during different stages of the developmental cycle .
- Post-Translational Modifications: Chlamydia trachomatis proteins undergo modifications that affect their function and interaction with host cell processes .
Chlamydia trachomatis has several applications in biomedical research and clinical practice:
- Biomedical Research: It serves as a model organism for studying host-pathogen interactions and intracellular parasitism .
- Diagnostic Tools: Nucleic acid amplification tests (NAATs) are commonly used to diagnose Chlamydia trachomatis infections .
- Therapeutic Strategies: Antibiotics such as azithromycin and doxycycline are effective in treating Chlamydia trachomatis infections .
Chlamydia trachomatis plays a crucial role throughout its life cycle:
- Development: The bacteria alternate between the infectious elementary body and the replicative reticulate body .
- Aging and Disease: Untreated infections can lead to chronic conditions such as pelvic inflammatory disease and infertility .
Chlamydia trachomatis remains a significant pathogen with profound implications for public health. Understanding its biology, mechanisms of action, and regulatory pathways is essential for developing effective diagnostic and therapeutic strategies.
