Viral Antigens
Product List
Parvovirus VP2
Parvovirus VP2 Canine Recombinant
Recombinant canine Parvovirus VP2 produced in SF9 is a glycosylated, polypeptide chain containing 584 a.a and having a calculated molecular mass of 64,657 Dalton. Parvovirus VP2 is purified by proprietary chromatographic techniques.
Sterile Filtered White lyophilized (freeze-dried) powder.
Parvovirus B19 VLP VP1
Parvovirus VLP VP1 Recombinant
Parvovirus B19 VLP VP1/VP2
Parvovirus B19 VLP VP1/VP2 Co-Capsid Recombinant
Recombinant Parvovirus B19 VLP VP1/VP2 Co-Capsid produced in SF9 containing B19 capsid proteins VP1 (81kDa) and VP2 (61kDa).
Parvovirus B19 VLP VP1/VP2 is purified by proprietary chromatographic techniques.
Parvovirus B19 VLP VP2
Parvovirus B19 VLP VP2 Recombinant
Parvovirus B19 VLP VP2 is purified by proprietary chromatographic techniques.
Introduction
Parvoviruses are small, non-enveloped viruses with a linear, single-stranded DNA genome of about 5-6 kilobases. They belong to the family Parvoviridae, which is divided into two subfamilies: Parvovirinae, infecting vertebrates, and Densovirinae, infecting invertebrates . Parvoviruses are further classified into several genera, including Erythroparvovirus, Dependoparvovirus, and Protoparvovirus .
Parvoviruses are characterized by their small size (23-28 nm in diameter) and rugged icosahedral capsid . They have a high level of genetic conservation, with two main open reading frames (ORFs) encoding nonstructural (NS) proteins and capsid proteins . The NS1 protein is crucial for viral replication and infection . Parvoviruses exhibit tissue-specific expression patterns, often targeting rapidly dividing cells .
Parvoviruses play significant roles in various biological processes. They are involved in immune responses and pathogen recognition. The viral capsid interacts with host receptors, facilitating entry into the host cell . The NS1 protein acts as a transcriptional activator and is essential for viral replication . Parvoviruses can also trigger immune responses by interacting with antibodies .
Parvoviruses enter host cells through endocytosis, utilizing cellular receptors to bind to the host cell . Once inside, they travel to the nucleus, where the viral genome is uncoated and replicated . The NS1 protein plays a key role in initiating replication and interacting with other cellular molecules . The viral capsid undergoes conformational changes to expose domains that facilitate membrane penetration .
The expression and activity of parvoviruses are tightly regulated. Transcriptional regulation involves the interaction of viral proteins with specific DNA motifs . Post-translational modifications, such as phosphorylation, also play a role in modulating the activity of viral proteins . The nuclear localization signals (NLS) in the capsid and nonstructural proteins are crucial for guiding the virus into the nucleus .
Parvoviruses have several applications in biomedical research and therapy. They are used as vectors for gene therapy, with adeno-associated viruses (AAVs) being a prominent example . Oncolytic parvoviruses are being explored for cancer treatment due to their ability to selectively infect and destroy tumor cells . Parvoviruses are also employed in diagnostic tools for detecting viral infections .
Throughout their life cycle, parvoviruses play various roles, from development to aging and disease. They infect host cells, replicate their genome, and produce progeny virions . The interaction between the viral NLS and host importin proteins is essential for nuclear entry and subsequent replication . Parvoviruses can persist in the host, sometimes leading to chronic infections .
