Viral Antigens
Product List
HBsAg adr CHO
Hepatitis B Surface Antigen, adr CHO Recombinant
HBsAg adw
Hepatitis B Surface Antigen, adw Recombinant
HBsAg adw CHO
Hepatitis B Surface Antigen Adw subtype Recombinant, CHO
Recombinant Hepatitis B Surface Antigen Adw subtype, CHO has a Mw of 23kDa, containing 226 amino acids and was purified from CHO cell line.
The Recombinant Hepatitis B Surface Antigen Adw subtype, CHO is purified by proprietary chromatographic technique.
Chinese Hamster Ovary Cells (CHO).
Sterile Filtered clear solution.
HBsAg adw2
Hepatitis B Surface Antigen, adw2 Recombinant
The HBsAg is fused to a 6 His tag on C-terminus and purified by proprietary chromatographic techniques.
HBsAg ayw
Hepatitis B Surface Antigen, ayw Recombinant
The Saccharomyces cerevisae derived recombinant full length protein contains the HBV surface antigen, having an Mw of 18kDa (ayw) and is fused to 6 His Tag at C-terminus. HBsAg runs as a multimer on SDS-PAGE ie. Momoner, Dimer, Trimer, etc...
HBsAg ayw, 31kDa
Hepatitis B Surface Antigen ayw Recombinant
HBsAg preS1
Hepatitis B Surface Antigen, preS1 Recombinant
HBsAg preS2
Hepatitis B Surface Antigen, preS2 Recombinant
Introduction
Hepatitis B surface antigen (HBsAg), also known as the Australia antigen, is a protein found on the surface of the hepatitis B virus (HBV). It is a key marker used in the diagnosis of hepatitis B infection . HBsAg is classified into three isoforms based on their size: large (LHB), middle (MHB), and small (SHB) surface proteins .
Key Biological Properties: HBsAg is a multifunctional glycoprotein that plays a crucial role in the viral life cycle and immune response. It is composed of 226 amino acids and has both hydrophilic and hydrophobic domains .
Expression Patterns: HBsAg is expressed on the surface of HBV and is released into the bloodstream during infection. It is present in high concentrations in the blood of infected individuals .
Tissue Distribution: HBsAg is primarily found in the liver, where HBV replicates. It can also be detected in other tissues and body fluids, including blood, saliva, and semen .
Primary Biological Functions: HBsAg is responsible for the initial attachment of HBV to hepatocytes, facilitating viral entry into the host cells . It also plays a role in the assembly and release of viral particles.
Role in Immune Responses: HBsAg elicits both humoral and cellular immune responses. It is a major target for neutralizing antibodies and cytotoxic T cells, which help control HBV infection .
Pathogen Recognition: HBsAg is recognized by the immune system as a foreign antigen, triggering an immune response aimed at eliminating the virus .
Mechanisms with Other Molecules and Cells: HBsAg interacts with various cellular receptors to facilitate viral entry and replication. It binds to the sodium taurocholate co-transporting polypeptide (NTCP) receptor on hepatocytes .
Binding Partners: HBsAg binds to host cell receptors and other viral proteins, such as the hepatitis B core antigen (HBcAg), to form the viral envelope .
Downstream Signaling Cascades: Upon binding to host cell receptors, HBsAg triggers signaling pathways that promote viral replication and immune evasion .
Transcriptional Regulation: The expression of HBsAg is regulated by viral promoters and enhancers. The HBV genome contains regulatory elements that control the transcription of HBsAg mRNA .
Post-Translational Modifications: HBsAg undergoes various post-translational modifications, including glycosylation, which are essential for its proper folding, stability, and function .
Biomedical Research: HBsAg is widely used in research to study HBV biology, pathogenesis, and immune responses. It serves as a model antigen for developing vaccines and antiviral therapies .
Diagnostic Tools: HBsAg detection is a cornerstone of HBV diagnosis. It is used in serological assays to screen for HBV infection and monitor treatment efficacy .
Therapeutic Strategies: HBsAg is a target for therapeutic vaccines and antiviral drugs aimed at achieving functional cure of chronic hepatitis B. Strategies include inducing HBsAg seroclearance and inhibiting its production .
Development to Aging and Disease: HBsAg plays a critical role throughout the HBV life cycle. It is involved in the initial infection, chronic infection, and disease progression. The persistence of HBsAg in the blood is associated with chronic hepatitis B, liver cirrhosis, and hepatocellular carcinoma .
