Viral Antigens
Product List
Zika Ectodomain
Zika Ectodomain Recombinant
The Zika Ectodomain is a recombinant protein of the ectodomain of the envelope protein from the Suriname Zika virus strain.
Zika Envelope
Zika Envelope Recombinant
The E.Coli derived Recombinant Zika Envelope protein having a Mw of 19kDa .The Zika Envelope protein is fused to a 6xHis tag at C-terminus and purified by proprietary chromatographic technique.
Zika Envelope Domain-3
Zika Envelope Domain-III Recombinant
Zika Envelope F.Length
Zika Envelope Full Length Protein Recombinant
The E.Coli derived Recombinant Zika Envelope protein 40-400 a.a. having an Mw of 45kDa. The Zika Envelope full length protein without a C-terminal hydrophobic region.
The Zika Envelope full length protein is fused to a 6xHis tag at C-terminus and purified by proprietary chromatographic technique.
Zika Envelope N
Zika Envelope N-Terminal Recombinant
Zika Envelope N protein is a peptide partially derived from zika envelope N terminal containing 270 amino acids, having an Mw of 30kDa and the Isoelectric point is 6.37.
The Zika Envelope N protein is fused to a 6xHis tag at C-terminus and purified by proprietary chromatographic technique.
Zika Envelope, sf9
Zika Envelope Recombinant, sf9
The Zika Envelope protein is fused to a 6xHis tag and purified by proprietary chromatographic technique.
Zika NS1
Zika NS1 Protein Recombinant
The Zika NS1 protein is fused to a 6xHis tag at C-terminus and purified by proprietary chromatographic technique.
Zika NS1, HEK
Zika NS1 Protein Recombinant, HEK
The Zika NS1 protein is fused to a 6xHis tag at C-terminus and purified by proprietary chromatographic technique.
Zika NS1, sf9
Zika NS1 Protein Recombinant, sf9
The Zika NS1 protein is fused to a 6xHis tag and purified by proprietary chromatographic technique.
Introduction
The Zika virus (ZIKV) is a mosquito-borne flavivirus that belongs to the family Flaviviridae and the genus Flavivirus . It is closely related to other flaviviruses such as dengue, yellow fever, Japanese encephalitis, and West Nile viruses . ZIKV was first identified in a rhesus monkey in Uganda’s Zika Forest in 1947 and later in humans in 1952 .
Key Biological Properties: ZIKV is an enveloped, icosahedral virus with a nonsegmented, single-stranded, positive-sense RNA genome of approximately 10.8 kilobases . The genome encodes a polyprotein that is cleaved into three structural proteins (capsid, envelope, and membrane) and seven nonstructural proteins .
Expression Patterns and Tissue Distribution: ZIKV primarily infects and replicates in various tissues, including the placenta and brain . It has been found in neural progenitor cells, astrocytes, and microglial cells .
Primary Biological Functions: ZIKV’s primary function is to replicate within host cells and produce viral progeny. It plays a significant role in immune responses and pathogen recognition by interacting with host cell receptors and immune cells .
Role in Immune Responses and Pathogen Recognition: ZIKV infection triggers immune responses, including the production of neutralizing antibodies and activation of immune cells. The virus can evade immune detection by modulating host immune pathways .
Mechanisms with Other Molecules and Cells: ZIKV interacts with host cell receptors, such as the envelope glycoprotein, to attach and enter human cells . It exploits cellular machinery for replication and assembly of new virions .
Binding Partners and Downstream Signaling Cascades: The virus binds to specific receptors on host cells, leading to endocytosis and release of viral RNA into the cytoplasm. This triggers downstream signaling cascades that facilitate viral replication and immune evasion .
Regulatory Mechanisms Controlling Expression and Activity: ZIKV infection activates the antioxidant nuclear factor erythroid 2-related factor 2 (Nrf2), which precedes oxidative stress . The virus also modulates host cell metabolism and homeostasis to promote its replication .
Transcriptional Regulation and Post-Translational Modifications: ZIKV relies on host cell machinery for transcription and translation of its genome. Post-translational modifications of viral proteins are essential for viral assembly and maturation .
Biomedical Research: ZIKV has become a focal point in biomedical research due to its association with severe congenital anomalies and neurological disorders . Research efforts aim to understand its pathogenesis, develop diagnostic tools, and identify therapeutic targets .
Diagnostic Tools: Diagnostic methods for ZIKV include molecular techniques such as RT-PCR to detect viral RNA and serological tests to identify antibodies .
Therapeutic Strategies: Current therapeutic strategies focus on developing antiviral drugs and vaccines to prevent ZIKV infection. Several candidate vaccines are in various stages of clinical trials .
Role Throughout the Life Cycle: ZIKV is maintained in an enzootic cycle involving forest-dwelling Aedes mosquitoes and non-human primates . In humans, the virus can be transmitted through mosquito bites, sexual contact, and from mother to fetus . The virus’s ability to infect and replicate in various tissues, including the placenta and brain, contributes to its pathogenicity and impact on human health .
ZIKV’s life cycle involves attachment to host cell receptors, entry via endocytosis, replication of viral RNA, assembly of new virions, and release from the host cell . The virus’s dependence on host cell machinery for replication and its ability to evade immune responses are critical for its survival and propagation .
