Viral Antigens
Product List
M.Pneumoniae P116
Mycoplasma Pneumoniae P116 Recombinant
The Recombinant Mycoplasma Pneumoniae P116 was expressed in E. coli having an Mw of 116 kDa. P116 is fused to a His-Tag.
M.Pneumoniae P1-C
Mycoplasma Pneumoniae P1-C Recombinant
This peptide can be used as an antigen in the diagnosis of M. pneumoniae infection.
M.Pneumoniae P30
Mycoplasma Pneumoniae P30 Recombinant
M.Pneumoniae P30 Recombinant produced in E.Coli is a non-glycosylated polypeptide chain having a molecular mass of 18-19kDa.
M.Pneumoniae P30 is fused to a 6 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
U. Urealyticum
Ureaplasma Urealyticum Parvum Recombinant
Introduction
Mycoplasma is a genus of bacteria that lack a cell wall around their cell membrane. This characteristic makes them unique among prokaryotes and resistant to many common antibiotics, such as penicillin, that target cell wall synthesis. Mycoplasma species are classified under the class Mollicutes, which is derived from the Latin term “mollis” meaning soft, referring to their lack of a rigid cell wall.
Key Biological Properties:
- Lack of Cell Wall: Mycoplasma species lack a peptidoglycan cell wall, making them pleomorphic (able to change shape).
- Small Genome: They have one of the smallest genomes of any self-replicating organism, which contributes to their minimalistic cellular machinery.
- Membrane Composition: Their cell membrane contains sterols, which are typically found in eukaryotic cells, providing stability and fluidity.
Expression Patterns:
- Mycoplasma species exhibit varied gene expression patterns depending on their environment and the host they infect.
Tissue Distribution:
- Mycoplasma can be found in various tissues, including the respiratory and urogenital tracts, and are known to infect both animals and plants.
Primary Biological Functions:
- Pathogenicity: Many Mycoplasma species are pathogenic and can cause diseases in humans, animals, and plants.
- Immune Evasion: They have evolved mechanisms to evade the host immune system, such as antigenic variation.
Role in Immune Responses:
- Mycoplasma can modulate host immune responses, often leading to chronic infections.
Pathogen Recognition:
- The host immune system recognizes Mycoplasma through pattern recognition receptors (PRRs) that detect pathogen-associated molecular patterns (PAMPs).
Mechanisms with Other Molecules and Cells:
- Mycoplasma interacts with host cells through surface adhesins that facilitate attachment and colonization.
Binding Partners:
- They bind to host cell receptors, extracellular matrix components, and other microbial surfaces.
Downstream Signaling Cascades:
- Interaction with host cells can trigger signaling pathways that lead to inflammation, immune response modulation, and tissue damage.
Regulatory Mechanisms Controlling Expression and Activity:
- Transcriptional Regulation: Mycoplasma species regulate gene expression through promoter sequences and transcription factors.
- Post-Translational Modifications: Protein activity can be modulated by phosphorylation, acetylation, and other modifications.
Biomedical Research:
- Mycoplasma is used as a model organism to study minimal cellular life and genome reduction.
Diagnostic Tools:
- Detection of Mycoplasma contamination is crucial in cell culture and biopharmaceutical production.
Therapeutic Strategies:
- Research is ongoing to develop vaccines and targeted therapies against Mycoplasma infections.
Role Throughout the Life Cycle:
- Development: Mycoplasma can infect hosts at various stages of development, from embryonic stages to adulthood.
- Aging and Disease: Chronic Mycoplasma infections can contribute to age-related diseases and conditions.
