Chlamydia PGP-3D
Description
Product Specs
Product Science Overview
The plasmid of Chlamydia trachomatis, particularly the pgp3 gene, has been identified as highly polymorphic, while pgp4 is the most conserved . The plasmid plays a crucial role in the bacterium’s ability to cause disease, with specific genovars associated with distinct disease pathologies. For instance, genovars A-C are linked to conjunctival infections, D-K to urogenital, pharyngeal, and anorectal infections, and L1-L3 to lymphogranuloma venereum (LGV) .
Recombinant studies of Chlamydia trachomatis have demonstrated that the bacterium can actively recombine both in vitro and in vivo . These studies have utilized whole-genome sequencing to explore the process of recombination, identifying that homologous recombination is the primary mechanism. No specific nucleotide sequences have been found to be preferentially used for recombination in vitro .
The Chlamydia Trachomatis PGP-3D recombinant protein is derived from E. coli and contains the full-length protein epitope of the pgp3 gene. This recombinant protein is fused to a 6xHis-Tag at the C-terminus, facilitating its purification and study . The pgp3 gene is a significant focus of research due to its polymorphic nature and its role in the bacterium’s pathogenicity .
Understanding the genetic diversity and recombination mechanisms of Chlamydia trachomatis is crucial for developing effective treatments and preventive measures. The recombinant PGP-3D protein serves as a valuable tool in studying the bacterium’s biology and its interaction with host cells . This research is essential for addressing the persistent rates of Chlamydia trachomatis infections globally and mitigating its impact on public health .
