Viral Antigens
Product List
T.pallidum TmpA partial
Treponema pallidum TmpA (partial) Recombinant
Treponema Mosaic
Treponema pallidum Mosaic Recombinant
Recombinant Treponema pallidum Mosaic contains TP15, TP17 & TP47 epitopes containing 382 a.a. produced in E.Coli and fused to a 6xHis tag at C-terminus. The total Mw is 38kDa and purified by proprietary chromatographic techniques.
Treponema p17 16.4kDa
Treponema pallidum p17, 16.4kDa Recombinant
Treponema p17 22kDa
Treponema pallidum p17, 22 kDa Recombinant
Recombinant Treponema pallidum p17 derived from full length TP17 gene containing 139 aa produced in E.Coli and fused to a 6xHis tag at C-terminus. The total Mw is 22kDa and the pI is 8.7, was purified by proprietary chromatographic techniques.
Treponema p47 47.7kDa
Treponema pallidum p47 47.7kDa Recombinant
Recombinant Treponema pallidum p47 derived from full length TPN47 gene is fused to a 6xHis tag at C-terminus. The total Mw is 47kDa and the pI is 5.86, was purified by proprietary chromatographic techniques.
Treponema TmpA 45kDa
Treponema pallidum TmpA, 45kDa Recombinant
Treponema TP0453
Outer Membrane Protein Treponema pallidum Recombinant
Recombinant Treponema pallidum Outer Membrane Protein TP0453 has a Mw of 26kDa, and was purified from E. coli.
The Recombinant Treponema pallidum Outer Membrane Protein TP0453 is fused to 6 amino acid His tag at its C terminal and purified by proprietary chromatographic technique.
Introduction
Treponema is a genus of spiral-shaped bacteria belonging to the family Spirochaetaceae. These bacteria are characterized by their helical shape and motility. The genus includes both pathogenic and non-pathogenic species. The most notable pathogenic species is Treponema pallidum, which is responsible for diseases such as syphilis, bejel, and yaws .
Key Biological Properties: Treponema species are helical, tightly coiled, and motile bacteria, ranging from 5–20 µm in length and 0.1–0.4 µm in diameter . They have a thick phospholipid membrane and a very slow rate of metabolism . Treponema pallidum, for instance, lacks a tricarboxylic acid cycle and processes for oxidative phosphorylation, resulting in minimal metabolic activity .
Expression Patterns and Tissue Distribution: Treponema species are obligate parasites, meaning they require a host to survive. They are found in various tissues, including the genitalia, oral cavity, and gastrointestinal tract . Treponema pallidum is known to be transmitted only among humans and baboons .
Primary Biological Functions: Treponema species play a crucial role in their host’s microbiome. Pathogenic species like Treponema pallidum are responsible for causing chronic diseases such as syphilis .
Role in Immune Responses and Pathogen Recognition: Treponema pallidum has evolved mechanisms to evade the host’s immune system. Its outer membrane proteins (OMPs) are key factors for pathogenesis, persistence, and immune evasion . The relatively low protein content of the outer membrane prevents antigen recognition by the immune system .
Mechanisms with Other Molecules and Cells: Treponema pallidum interacts with host cells through its outer membrane proteins. These proteins facilitate attachment to host cells and play a role in immune evasion .
Binding Partners and Downstream Signaling Cascades: The outer membrane proteins of Treponema pallidum interact with host cell receptors, initiating signaling cascades that facilitate bacterial invasion and immune evasion .
Regulatory Mechanisms Controlling Expression and Activity: The expression of Treponema pallidum’s outer membrane proteins is tightly regulated. This regulation is crucial for the bacterium’s ability to evade the host’s immune system and establish infection .
Transcriptional Regulation and Post-Translational Modifications: The regulatory mechanisms include transcriptional regulation and post-translational modifications of outer membrane proteins, which are essential for the bacterium’s pathogenicity .
Diagnostic Tools: Treponema pallidum’s outer membrane proteins are used as biomarkers for the diagnosis of syphilis . Rapid tests can provide results in a few minutes, facilitating immediate treatment initiation .
Therapeutic Strategies: Research is ongoing to develop vaccines targeting Treponema pallidum’s outer membrane proteins. These vaccines aim to provide immune protection against syphilis .
Role Throughout the Life Cycle: Treponema species play a role throughout their host’s life cycle. For instance, Treponema pallidum can be transmitted from mother to baby during childbirth, leading to congenital syphilis . The bacterium’s ability to evade the immune system allows it to persist in the host for extended periods, contributing to chronic disease .
