Treponema Mosaic
Sterile Filtered solution.
Treponema Mosaic is >95% pure as determined by 10% PAGE (coomassie staining).
Description
Recombinant Treponema pallidum Mosaic contains TP15, TP17 & TP47 epitopes containing 382 a.a. produced in E.Coli and fused to a 6xHis tag at C-terminus. The total Mw is 38kDa and purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
Recombinant proteins are artificially produced proteins that are used in various diagnostic and therapeutic applications. In the context of Treponema pallidum, several recombinant proteins have been developed to improve the accuracy of syphilis diagnosis. These proteins include TmpA, TpN17, and TpN47, which have shown varying degrees of sensitivity and specificity in serological tests .
- TmpA: This protein has shown high specificity but lower sensitivity in serological tests.
- TpN17: Known for its high specificity and moderate sensitivity, making it a reliable marker in syphilis diagnosis.
- TpN47: Exhibits the highest accuracy among the tested recombinant proteins, with high sensitivity and specificity .
Mosaic recombinant proteins are engineered by combining sequences from different strains or variants of a pathogen. This approach aims to create a more comprehensive antigen that can elicit a stronger immune response or improve diagnostic accuracy. In the case of Treponema pallidum, mosaic recombinant proteins are designed to include epitopes from multiple strains, enhancing their ability to detect diverse variants of the bacterium .
The development of mosaic recombinant proteins for Treponema pallidum has significant implications for both diagnostics and vaccine development. By incorporating multiple epitopes, these proteins can improve the sensitivity and specificity of serological tests, leading to more accurate diagnoses. Additionally, they hold promise for the development of a universal syphilis vaccine that can provide broad protection against various strains of the bacterium .
