Monoclonal Antibodies
Product List
Mab HP3/17 is a Protein G affinity purified monoclonal antibody raised against a polypeptide from the 50 kDa subunit of Heparanase.
Introduction
Anti Human Enzymes are a class of enzymes that specifically target and inhibit the activity of human enzymes. These enzymes are often used in therapeutic and diagnostic applications to modulate biological processes. Enzymes are classified based on the type of reaction they catalyze, and the classification system includes seven major categories: oxidoreductases, transferases, hydrolases, lyases, isomerases, ligases, and translocases .
Key Biological Properties: Anti Human Enzymes exhibit high specificity and catalytic efficiency. They are designed to interact with specific human enzymes, inhibiting their activity.
Expression Patterns: These enzymes can be expressed in various systems, including bacterial, yeast, and mammalian cells, depending on the desired application.
Tissue Distribution: The distribution of Anti Human Enzymes depends on their target human enzyme. For instance, enzymes targeting digestive enzymes will be prevalent in the gastrointestinal tract, while those targeting metabolic enzymes may be found in the liver .
Primary Biological Functions: The main function of Anti Human Enzymes is to inhibit the activity of specific human enzymes. This inhibition can regulate various biological processes, including metabolism, immune responses, and cell signaling.
Role in Immune Responses and Pathogen Recognition: Anti Human Enzymes can modulate immune responses by inhibiting enzymes involved in inflammation and immune cell activation. They can also play a role in pathogen recognition by targeting enzymes that pathogens use to evade the immune system .
Mechanisms with Other Molecules and Cells: Anti Human Enzymes interact with their target enzymes through specific binding sites, leading to the inhibition of the enzyme’s activity. This interaction can involve competitive inhibition, where the enzyme competes with the substrate, or non-competitive inhibition, where the enzyme binds to a different site on the enzyme.
Binding Partners and Downstream Signaling Cascades: The binding of Anti Human Enzymes to their targets can affect downstream signaling pathways. For example, inhibiting a kinase can prevent the phosphorylation of downstream targets, altering cellular responses .
Regulatory Mechanisms: The expression and activity of Anti Human Enzymes are regulated at multiple levels. Transcriptional regulation involves the control of gene expression by transcription factors. Post-translational modifications, such as phosphorylation and ubiquitination, can also modulate enzyme activity and stability .
Biomedical Research: Anti Human Enzymes are valuable tools in research for studying enzyme function and regulation. They can be used to dissect signaling pathways and understand disease mechanisms.
Diagnostic Tools: These enzymes can be used in diagnostic assays to detect the presence or activity of specific human enzymes, aiding in disease diagnosis.
Therapeutic Strategies: Anti Human Enzymes have therapeutic potential in treating diseases caused by overactive or dysregulated enzymes. For example, enzyme inhibitors are used in cancer therapy to target enzymes involved in cell proliferation .
Role Throughout the Life Cycle: Anti Human Enzymes play a role in various stages of life, from development to aging. During development, they can regulate enzymes involved in cell differentiation and growth. In aging, they can modulate enzymes that contribute to age-related diseases. In disease, they can target enzymes that are dysregulated, providing therapeutic benefits .
