GSTT1 Antibody
Description
Product Specs
Product Science Overview
Glutathione S-Transferase Theta-1 (GSTT1) is an enzyme that belongs to the glutathione S-transferase (GST) superfamily. This family of enzymes plays a crucial role in the detoxification process by catalyzing the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds . GSTT1 is one of the key members of the theta class of GSTs, which also includes GSTT2 and GSTT2B .
GSTT1 is involved in the neutralization of electrophilic compounds, including carcinogens, by facilitating their conjugation with glutathione . This process is essential for the detoxification of harmful substances and protection against oxidative stress. The enzyme displays glutathione peroxidase activity, which helps in reducing hydroperoxides .
The expression of GSTT1 varies among different tissues. It is predominantly found in the liver, where it plays a significant role in detoxification processes. However, it is also expressed in other tissues such as the kidney, lung, and gastrointestinal tract . The expression patterns of GSTT1 can be influenced by various factors, including genetic polymorphisms and environmental exposures .
The primary function of GSTT1 is to catalyze the conjugation of glutathione to electrophilic compounds, thereby neutralizing their reactivity and facilitating their excretion from the body . This activity is crucial for protecting cells from oxidative damage and maintaining cellular homeostasis. Additionally, GSTT1 has been implicated in the metabolism of various endogenous and exogenous compounds, including drugs and environmental toxins .
GSTT1 exerts its detoxifying effects through its enzymatic activity, which involves the transfer of the glutathione moiety to electrophilic substrates . This reaction results in the formation of less reactive and more water-soluble conjugates that can be readily excreted from the body. The enzyme’s activity is dependent on the availability of reduced glutathione and the presence of suitable substrates .
The expression and activity of GSTT1 are regulated by multiple factors, including genetic polymorphisms, transcriptional regulation, and post-translational modifications . Genetic variations in the GSTT1 gene can lead to differences in enzyme activity and susceptibility to certain diseases . Environmental factors, such as exposure to toxins and dietary components, can also influence the expression and activity of GSTT1 .
