GSK3B Antibody

Glycogen synthase kinase-3 beta (GSK-3β) is a serine/threonine kinase that plays a crucial role in various cellular processes. It is one of the two isoforms of glycogen synthase kinase-3 (GSK-3), the other being GSK-3 alpha (GSK-3α). GSK-3β is encoded by the GSK3B gene in humans and the Gsk3b gene in mice . This enzyme is involved in numerous cellular functions, including glycogen metabolism, cell cycle regulation, apoptosis, embryonic development, cell differentiation, and inflammation .

GSK-3β is a multifunctional enzyme that phosphorylates and regulates the function of more than 50 substrates . It acts as a point of convergence for various cell-signaling pathways, influencing essential cellular functions such as:

• Glycogen metabolism
• Cell cycle control
• Apoptosis
• Embryonic development
• Cell differentiation
• Cell motility
• Microtubule function
• Cell adhesion
• Inflammation

GSK-3β plays a fundamental role in the inflammatory response induced by bacterial pathogens. Depending on the pathogen and its virulence factors, GSK-3β may either promote or inhibit inflammation . It modulates inflammatory signaling in monocytes/macrophages and epithelial cells at the transcriptional level, primarily through the regulation of nuclear factor-kappaB (NF-κB) activity .

Abnormal regulation and expression of GSK-3β are associated with various diseases, including bipolar disorder . In mice, the ablation of the GSK-3β isoform results in embryonic lethality due to hepatocyte apoptosis, indicating the critical role of this enzyme in liver function and development .

Mouse anti-human GSK-3β antibodies are commonly used in research to study the enzyme’s function and regulation. These antibodies are designed to specifically bind to the human GSK-3β protein, allowing researchers to investigate its role in various cellular processes and disease states .