GSTT2 Antibody
Description
Product Specs
Product Science Overview
GSTT2 belongs to the theta class of GSTs, which also includes GSTT1 and GSTT2B. These enzymes share a significant degree of amino acid sequence identity and are thought to have important roles in human carcinogenesis . The theta class GSTs are composed of five exons with identical exon/intron boundaries .
The primary function of GSTT2 is to facilitate the conjugation of reduced glutathione to various exogenous and endogenous hydrophobic electrophiles . This activity is essential for the detoxification of harmful compounds and the protection of cellular components from oxidative damage .
The mouse anti-human GSTT2 antibody is a monoclonal antibody specifically designed to target and bind to the human GSTT2 protein. This antibody is commonly used in research to study the expression and function of GSTT2 in various biological contexts. It can be employed in techniques such as Western blotting, immunohistochemistry, and enzyme-linked immunosorbent assays (ELISA) to detect and quantify GSTT2 levels in human tissues and cells.
Research on GSTT2 has revealed its involvement in several biological pathways and its potential role in various diseases. For instance, GSTT2 has been implicated in the biotransformation of xenobiotics and the metabolism of glutathione . Additionally, studies have suggested that GSTT2 may play a role in the development of certain cancers, making it a potential target for therapeutic interventions .
In clinical settings, the mouse anti-human GSTT2 antibody can be used to investigate the expression patterns of GSTT2 in different tissues and to explore its potential as a biomarker for disease diagnosis and prognosis. Understanding the function and regulation of GSTT2 could provide valuable insights into the mechanisms underlying detoxification processes and the development of diseases related to oxidative stress and carcinogenesis.
