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Monoclonal Antibodies

Other Monoclonal Antibodies

Anti Human Lymphocyte

Anti Mouse Cytokine

Anti Human Cytokine

Anti Mouse Lymphocyte

Anti-GST Monoclonal

Anti Viral Monoclonal

Anti Human Heat Shock Protein

Anti Human Enzyme

Product List

HA-HRP Antibody

HA Mouse Antibody, Peroxidase Conjugated

Monoclonal antibodies are produced by immunizing mouse with synthetic peptide (YPYDVPDYA) coupled to KLH.

Shipped with Ice Packs

Cat. No.

BT19238

Source

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HA-tag Antibody

HA-tag peptide, Mouse Antibody

Shipped with Ice Packs

Cat. No.

BT19320

Source

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HA-tag Peptide PAT5E7AT Antibody

HA-tag peptide Clone PAT5E7AT, Mouse Anti Human

Shipped with Ice Packs

Cat. No.

BT19422

Source

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Sterile filtered colorless solution.

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HAX1 Antibody

HCLS1-associated protein X-1, Mouse Anti Human

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Cat. No.

BT19515

Source

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HBsAg Recom. Antibody

Hepatitis B virus surface antigen Ck Recombinant Antibody

HBsAg is a serological marker produced on the surface of the hepatitis B virus and is one of the first disease state markers to be detected in the serum of patients infected with the hepatitis B virus. Recombinant Anti HbsAg produced in E.Coli is a non-glycosylated, polypeptide chain containing an amino-terminal hexahistidine tag and a carboxyterminal kappa constant region tag and having a molecular weight of 43 kDa.
HBsAg is purified by proprietary chromatographic techniques.

Shipped with Ice Packs

Cat. No.

BT19598

Source

Escherichia Coli.

Appearance

Sterile Filtered clear solution.

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HCG-b core antibody

Human Chorionic Gonadotropin beta core, Mouse antibody

Shipped with Ice Packs

Cat. No.

BT19672

Source

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HEL antibody

Hen Egg Lysozyme, Mouse antibody

Shipped with Ice Packs

Cat. No.

BT19737

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HINT2 Antibody

Histidine Triad Nucleotide Binding Protein 2, Mouse Anti Human

Shipped with Ice Packs

Cat. No.

BT19804

Source

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Sterile filtered colorless solution.

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His Tag Antibody

Polyhistidine Tag, Mouse Antibody

Monoclonal antibodies are produced by immunizing mouse with synthesized polypeptide 6 x His. This antibody was purified via protein-A affinity chromatography.

Shipped with Ice Packs

Cat. No.

BT19909

Source

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Sterile Filtered solution.

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HMGB1 Antibody

High-Mobility Group Box 1, Mouse Anti Human

Shipped with Ice Packs

Cat. No.

BT20125

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Introduction

Definition and Classification

Monoclonal antibodies (mAbs) are laboratory-produced molecules engineered to serve as substitute antibodies that can restore, enhance, or mimic the immune system’s attack on cells. They are produced by identical immune cells that are all clones of a unique parent cell. Monoclonal antibodies can be classified based on their source and structure:

Murine mAbs: Derived from mouse cells.
Chimeric mAbs: Contain both human and mouse components.
Humanized mAbs: Mostly human, with only small mouse-derived components.
Human mAbs: Fully human antibodies.

Biological Properties

Monoclonal antibodies exhibit several key biological properties:

Protein Sequence: Identical protein sequences and antigen-binding sites.
Expression Patterns: Produced by B lymphocytes and expressed in hybridoma cells.
Tissue Distribution: Can be designed to target specific tissues or cells, such as cancer cells.

Biological Functions

Monoclonal antibodies play crucial roles in the immune system:

Pathogen Recognition: Bind to specific antigens on pathogens, marking them for destruction.
Immune Response: Enhance the immune system’s ability to fight infections and diseases.
Therapeutic Functions: Used in treating various diseases, including cancer, autoimmune disorders, and infectious diseases.

Modes of Action

Monoclonal antibodies interact with other molecules and cells through various mechanisms:

Binding Partners: Bind to specific antigens on target cells.
Downstream Signaling Cascades: Trigger immune responses by activating immune cells and complement systems.
Effector Functions: Engage Fc receptors on immune cells, leading to cell-mediated cytotoxicity.

Regulatory Mechanisms

The expression and activity of monoclonal antibodies are tightly regulated:

Transcriptional Regulation: Controlled by specific transcription factors that regulate the expression of antibody genes.
Post-Translational Modifications: Undergo modifications such as glycosylation, which can affect their stability and function.

Applications

Monoclonal antibodies have a wide range of applications in biomedical research and medicine:

Diagnostic Tools: Used in assays to detect specific antigens in samples.
Therapeutic Strategies: Employed in the treatment of cancers, autoimmune diseases, and infectious diseases.
Biomedical Research: Serve as tools to study cellular processes and disease mechanisms.

Role in the Life Cycle

Monoclonal antibodies play roles throughout the life cycle:

Development: Used in prenatal diagnostics and treatments.
Aging: Help manage age-related diseases such as cancer and Alzheimer’s.
Disease: Provide targeted therapies for various diseases, improving patient outcomes.