HCG-b core antibody
Description
Product Specs
Product Science Overview
Human Chorionic Gonadotropin (hCG) is a glycoprotein hormone produced during pregnancy by the placenta. It is composed of two subunits: alpha and beta. The beta subunit is unique to hCG and is often used in various diagnostic and research applications. The beta core fragment of hCG (hCGβcf) is a degradation product of the hCG beta subunit and is found in urine. Mouse antibodies targeting the hCG beta core fragment are valuable tools in research and clinical diagnostics.
hCG is composed of two non-identical, non-covalently linked polypeptide chains: the alpha and beta subunits. The alpha subunit is common to other glycoprotein hormones such as thyroid-stimulating hormone (TSH), follicle-stimulating hormone (FSH), and luteinizing hormone (LH). The beta subunit, however, is unique to hCG and confers its biological specificity.
The primary function of hCG is to maintain the corpus luteum during the early stages of pregnancy, ensuring the continued production of progesterone, which is crucial for maintaining the uterine lining and supporting fetal development.
The hCG beta core fragment (hCGβcf) is a degradation product of the hCG beta subunit. It is found in the urine of pregnant women and can be used as a marker for certain cancers, such as trophoblastic tumors and testicular cancer. The detection of hCGβcf is important in both clinical diagnostics and research settings.
Mouse monoclonal antibodies targeting the hCG beta core fragment are widely used in research and diagnostic applications. These antibodies are generated by immunizing mice with the hCG beta core fragment, leading to the production of specific antibodies that can be harvested and purified.
Applications
- Enzyme-Linked Immunosorbent Assay (ELISA): Mouse antibodies against hCG beta core are commonly used in ELISA to detect and quantify hCGβcf in biological samples.
- Immunohistochemistry (IHC): These antibodies can be used to stain tissue samples, allowing for the visualization of hCGβcf in various tissues.
- Western Blotting: Mouse antibodies against hCG beta core can be used to detect hCGβcf in protein samples separated by gel electrophoresis.
Specificity and Sensitivity
Mouse monoclonal antibodies against hCG beta core are highly specific and sensitive. They are designed to bind to a specific epitope on the hCG beta core fragment, ensuring accurate detection and quantification. For example, the antibody INN-hCG-106 is known for its high specificity and is suitable for use in ELISA and other applications.
