HBsAg Recom. Antibody
Analysis by SDS-PAGE.
Description
HBsAg is a serological marker produced on the surface of the hepatitis B virus and is one of the first disease state markers to be detected in the serum of patients infected with the hepatitis B virus. Recombinant Anti HbsAg produced in E.Coli is a non-glycosylated, polypeptide chain containing an amino-terminal hexahistidine tag and a carboxyterminal kappa constant region tag and having a molecular weight of 43 kDa.
HBsAg is purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
Hepatitis B virus (HBV) is a significant global health concern, causing both acute and chronic liver infections. One of the key markers used in the diagnosis and monitoring of HBV infection is the Hepatitis B surface antigen (HBsAg). The development of recombinant antibodies against HBsAg has been a crucial advancement in the field of diagnostics and therapeutics. This article delves into the background of the Hepatitis B virus surface antigen Ck recombinant antibody, its significance, and its applications.
HBV is a DNA virus that primarily infects the liver. It has a complex structure with several antigens, among which the surface antigen (HBsAg) is the most important for diagnostic purposes. HBsAg is the first serologic marker to appear in a new acute infection and can be detected as early as one week after exposure to the virus . The presence of HBsAg in the blood indicates an active HBV infection, whether acute or chronic .
Recombinant antibodies are engineered antibodies produced through recombinant DNA technology. These antibodies are designed to target specific antigens with high specificity and affinity. The production of recombinant antibodies involves the insertion of the gene encoding the desired antibody into a host cell, which then expresses the antibody. This technology allows for the large-scale production of antibodies with consistent quality and specificity.
The Hepatitis B virus surface antigen Ck recombinant antibody is a monoclonal antibody specifically designed to bind to the HBsAg. This antibody is produced using recombinant DNA technology, ensuring high purity and specificity. The “Ck” in its name refers to the constant region of the kappa light chain, which is a part of the antibody structure.
-
Diagnostic Use: The primary application of the Hepatitis B virus surface antigen Ck recombinant antibody is in the diagnosis of HBV infection. It is used in various immunoassays, such as enzyme-linked immunosorbent assays (ELISAs) and rapid diagnostic tests (RDTs), to detect the presence of HBsAg in blood samples . These tests are crucial for screening blood donations, diagnosing HBV infections, and monitoring the effectiveness of antiviral therapy.
-
Therapeutic Potential: While the primary use of this recombinant antibody is diagnostic, there is potential for therapeutic applications. Monoclonal antibodies against HBsAg could be used to neutralize the virus and prevent its spread within the body. Research is ongoing to explore the therapeutic potential of these antibodies in treating chronic HBV infections.
-
Research Tool: The Hepatitis B virus surface antigen Ck recombinant antibody is also a valuable tool in research. It is used in various studies to understand the structure and function of HBsAg, as well as the immune response to HBV infection. This antibody helps in the development of new diagnostic methods and therapeutic strategies.
