Hormones
Product List
GHRH Human
Growth Hormone Releasing Hormone Human
Corresponds to the amino-terminal segment of the naturally occurring human growth hormone-releasing hormone consisting of 44 amino acid residues.
The GHRH is purified by proprietary chromatographic techniques.
GHRP 6
Growth Hormone Releasing Peptide-6
GHRP1
Growth Hormone Releasing Peptide-1
Growth Hormone Releasing Peptide-1 Synthetic is a single, non-glycosylated polypeptide chain containing 5 amino acids, having a molecular mass of 955.11 Dalton and a Molecular formula of C51H62N12O7.
GHRP2
Growth Hormone Releasing Peptide-2
GHRP4
Growth Hormone Releasing Peptide-4
Growth Hormone Releasing Peptide-4 Synthetic is a single, non-glycosylated polypeptide chain containing 4 amino acids, having a molecular mass of 607.73 Dalton and a Molecular formula of C34H37N7O4.
GHRP5
Growth Hormone Releasing Peptide-5
Growth Hormone Releasing Peptide-5 Synthetic is a single, non-glycosylated polypeptide chain containing 5 amino acids, having a molecular mass of 770.91 Dalton and a Molecular formula of C43H46N8O6.
Ipamorelin
Ipamorelin
Ipamorelin Synthetic is a single, non-glycosylated polypeptide chain containing 4 amino acids, having a molecular mass of 711.85 Dalton and a Molecular formula of C38H49N9O5.
Introduction
Growth hormone-releasing peptides (GHRPs) are synthetic, non-natural peptides that stimulate the secretion of growth hormone (GH) from the pituitary gland. They do not share structural homology with growth hormone-releasing hormone (GHRH) and act via specific receptors located in the pituitary and hypothalamus . GHRPs include several peptides such as GHRP-6, GHRP-2, and Hexarelin .
GHRPs exhibit potent stimulatory effects on somatotrope secretion in both animals and humans . They are characterized by their ability to increase GH levels, which in turn influences various physiological processes. GHRPs are expressed in tissues such as the pituitary gland and hypothalamus . Their distribution is primarily in these regions, where they exert their effects by binding to specific receptors .
The primary biological function of GHRPs is to stimulate the release of growth hormone, which plays a crucial role in growth, metabolism, and overall physiological regulation . GHRPs also exhibit cytoprotective and cardioprotective properties, making them potential candidates for therapeutic applications in conditions such as myocardial infarction . Additionally, GHRPs have been shown to enhance muscle growth, improve recovery, and increase strength .
GHRPs exert their effects by binding to specific receptors in the hypothalamus and pituitary gland, known as growth hormone secretagogue receptors (GHSRs) . This binding triggers the release of growth hormone-releasing hormone (GHRH), which then stimulates the pituitary gland to release growth hormone . GHRPs also inhibit the release of somatostatin, a hormone that suppresses GH secretion . The downstream signaling cascades involve various intracellular pathways, including the activation of protein kinase C (PKC) and the influx of calcium ions .
The expression and activity of GHRPs are regulated by several mechanisms. Transcriptional regulation involves the interaction of various transcription factors with the promoter regions of GHRP genes . Post-translational modifications, such as phosphorylation, also play a role in modulating the activity of GHRPs . Additionally, the release of GHRPs is influenced by metabolic conditions, such as glucose and lipid levels, as well as hormonal signals from the hypothalamus .
GHRPs have several applications in biomedical research and clinical practice. They are used as diagnostic tools to assess growth hormone deficiency and other endocrine disorders . Therapeutically, GHRPs are explored for their potential in treating conditions such as muscle wasting, growth hormone deficiency, and age-related decline in GH levels . Their cytoprotective and cardioprotective properties also make them candidates for treating cardiovascular diseases .
Throughout the life cycle, GHRPs play a significant role in regulating growth and development. In childhood and adolescence, they contribute to growth and development by stimulating GH release . In adulthood, GHRPs help maintain muscle mass, bone density, and metabolic functions . As individuals age, the activity of GHRPs decreases, leading to a decline in GH levels and associated physiological functions . However, GHRPs can still exert beneficial effects in older adults by enhancing GH secretion and mitigating age-related decline .
