GHRP 6

Growth Hormone Releasing Peptide-6
Cat. No.
BT13210
Source
Synonyms
GHRP-6, GHRP.
Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
Purity

Greater than 98.0% as determined by analysis by RP-HPLC.

Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description

Growth Hormone Releasing Peptide-6 Synthetic is a single, non-glycosylated polypeptide chain containing 6 amino acids, having a molecular mass of 873 Dalton and a Molecular formula of C46H56N12O6.

Product Specs

Introduction
Growth hormone-releasing peptides (GHRPs) are synthetically produced peptides that, similar to growth hormone-releasing hormone (GHRH), directly affect pituitary somatotrophs to stimulate growth hormone (GH) release. The secretion of growth hormone (GH) is triggered by various synthetic secretagogues, with growth hormone-releasing hexapeptide (GHRP-6) being the most extensively researched among them. It is believed to exert its effects on both the pituitary gland and the hypothalamus.
Description
Synthetic Growth Hormone Releasing Peptide-6 is a single, non-glycosylated polypeptide chain comprising 6 amino acids. It possesses a molecular weight of 873 Daltons and is represented by the molecular formula C46H56N12O6.
Physical Appearance
White, sterile, and lyophilized (freeze-dried) powder.
Formulation
The GHRP-6 peptide was lyophilized without any additional ingredients.
Solubility
For reconstitution of the lyophilized GHRP-6, it is advisable to use sterile 18MΩ-cm H2O at a concentration of at least 100 μg/ml. Subsequently, it can be further diluted using other aqueous solutions.
Stability
Lyophilized Growth Hormone Releasing Peptide-6 demonstrates stability at room temperature for a period of 3 weeks. However, for optimal storage, it is recommended to store it in a desiccated state below -18°C. After reconstitution, GHRP-6 should be stored at 4°C for a duration of 2-7 days. For extended storage, it is recommended to freeze it below -18°C. The addition of a carrier protein (0.1% HSA or BSA) is advised for long-term storage. It is crucial to avoid repeated cycles of freezing and thawing.
Purity
Analysis by RP-HPLC has determined a purity exceeding 98.0%.
Synonyms
GHRP-6, GHRP.
Amino Acid Sequence

His-D-Trp-Ala-Trp-D-Phe-Lys-NH2.

Product Science Overview

Introduction

Growth Hormone Releasing Peptide-6 (GHRP-6) is a synthetic hexapeptide that has garnered significant attention in the fields of endocrinology and sports medicine. This peptide is known for its ability to stimulate the release of growth hormone (GH) from the pituitary gland, making it a potent growth hormone secretagogue .

Chemical Structure

GHRP-6 is composed of six amino acids, specifically L-histidyl-D-tryptophyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-lysineamide. Its molecular formula is C46H56N12O6, and it has a molar mass of 873.032 g/mol . The peptide includes unnatural D-amino acids, which contribute to its unique properties and effectiveness in stimulating GH release .

Mechanism of Action

GHRP-6 functions by binding to the ghrelin receptor, also known as the growth hormone secretagogue receptor (GHSR). This receptor is naturally activated by ghrelin, a peptide hormone that stimulates hunger and regulates GH secretion . When GHRP-6 binds to GHSR, it triggers a signaling cascade that leads to the pulsatile release of growth hormone from the pituitary gland . This pulsatile release mimics the natural pattern of GH secretion in the body, enhancing its physiological effects.

Physiological Effects

The primary effect of GHRP-6 is the stimulation of growth hormone release, which has several downstream effects on the body:

  • Muscle Growth: GH promotes protein synthesis and muscle hypertrophy, making GHRP-6 popular among athletes and bodybuilders .
  • Fat Breakdown: GH stimulates lipolysis, leading to a reduction in body fat .
  • Bone Density: GH enhances bone mineralization, improving bone density and strength .
  • Anti-Aging: Increased GH levels are associated with anti-aging effects, such as improved skin elasticity and reduced wrinkles .
Clinical Applications

GHRP-6 has been studied for its potential therapeutic applications in various conditions characterized by growth hormone deficiency. These include:

  • Short Stature: In children and adults with growth hormone deficiency, GHRP-6 can help increase height and improve overall growth .
  • Muscle Wasting: In conditions such as cachexia and sarcopenia, GHRP-6 can help preserve muscle mass and improve physical function .
  • Age-Related Decline: In older adults, GHRP-6 may counteract the age-related decline in growth hormone secretion, promoting better health and vitality .
Side Effects and Considerations

While GHRP-6 has many potential benefits, it is not without side effects. Common side effects include increased hunger, water retention, and joint pain . Additionally, the consumption of carbohydrates and dietary fats around the administration window of GHRP-6 can significantly blunt the GH release . Therefore, careful consideration of diet and timing is essential for maximizing the benefits of GHRP-6.

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THE BIOTEK
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