GHRP5
GHRP-5, GHRP5.
Greater than 97.0% as determined by analysis by RP-HPLC.
Description
Growth Hormone Releasing Peptide-5 Synthetic is a single, non-glycosylated polypeptide chain containing 5 amino acids, having a molecular mass of 770.91 Dalton and a Molecular formula of C43H46N8O6.
Product Specs
Growth hormone-releasing peptides (GHRPs) are a class of synthetic peptides that act on the pituitary gland to stimulate the release of growth hormone (GH), similar to the naturally occurring growth hormone-releasing hormone (GHRH). GHRP-5, a specific type of GHRP, is a synthetic analog of met-enkephalin, incorporating unnatural D-amino acids in its structure. Although structurally resembling opioids, GHRP-5 lacks opioid activity. Its primary function is to act as a potent stimulator of GH release. Unlike GHRH, GHRP-5 exerts its effects by binding to a distinct receptor known as the ghrelin receptor.
Synthetic Growth Hormone Releasing Peptide-5 is a single-chain polypeptide composed of 5 amino acids. It lacks any carbohydrate modifications (non-glycosylated) and has a molecular weight of 770.91 Daltons. Its molecular formula is C43H46N8O6.
The peptide is freeze-dried without any additional substances.
To reconstitute the lyophilized GHRP-5 powder, it is recommended to dissolve it in sterile 18MΩ-cm H2O at a concentration of at least 100 µg/ml. This solution can be further diluted with other aqueous solutions as needed.
Lyophilized Growth Hormone Releasing Peptide-5, though stable at room temperature for up to 3 weeks, should ideally be stored in a dry environment below -18°C. After reconstitution, the GHRP-5 solution should be kept refrigerated at 4°C for a maximum of 2-7 days. For longer storage periods, freezing the solution below -18°C is recommended. To enhance stability during long-term storage, consider adding a carrier protein like HSA or BSA at a concentration of 0.1%. Avoid repeated freezing and thawing of the peptide.
The purity of this product is determined to be greater than 97.0% using Reverse Phase-High Performance Liquid Chromatography (RP-HPLC).
GHRP-5, GHRP5.
Tyr-(D-Trp)-Ala-Trp-(D-Phe)-NH2.
Product Science Overview
Growth Hormone Releasing Peptide-5 (GHRP-5) is a synthetic peptide that belongs to the family of growth hormone-releasing peptides (GHRPs). These peptides are known for their ability to stimulate the secretion of growth hormone (GH) from the anterior pituitary gland. GHRP-5, like other GHRPs, has been studied for its potential therapeutic applications in various medical conditions, including growth hormone deficiency, muscle wasting, and aging.
GHRPs were first discovered in the 1980s when researchers were investigating the mechanisms of growth hormone release. The initial discovery of GHRP-6, a hexapeptide, led to the development of other GHRPs, including GHRP-5. These peptides were found to have potent GH-releasing properties, making them attractive candidates for further research and development.
GHRP-5 exerts its effects by binding to specific receptors known as growth hormone secretagogue receptors (GHS-R) located in the pituitary gland and hypothalamus . Upon binding to these receptors, GHRP-5 stimulates the release of growth hormone-releasing hormone (GHRH) from the hypothalamus, which in turn stimulates the pituitary gland to release GH . Additionally, GHRP-5 can directly stimulate the pituitary gland to release GH independently of GHRH .
The primary therapeutic application of GHRP-5 is in the treatment of growth hormone deficiency. By stimulating the release of GH, GHRP-5 can help increase growth and development in individuals with GH deficiency. Additionally, GHRP-5 has been studied for its potential benefits in muscle wasting conditions, such as those associated with chronic illnesses or aging . It may also have applications in improving bone density, enhancing immune function, and promoting overall well-being .
While GHRP-5 has shown promise in various therapeutic applications, it is important to consider its safety and potential side effects. Common side effects associated with GHRP-5 include increased appetite, water retention, and transient increases in blood sugar levels . Long-term use of GHRP-5 may also carry risks, such as the development of insulin resistance and potential impacts on cardiovascular health . Therefore, it is crucial to use GHRP-5 under the supervision of a qualified healthcare professional.
