GHRP4
GHRP-4, GHRP4.
Greater than 97.0% as determined by analysis by RP-HPLC.
Description
Growth Hormone Releasing Peptide-4 Synthetic is a single, non-glycosylated polypeptide chain containing 4 amino acids, having a molecular mass of 607.73 Dalton and a Molecular formula of C34H37N7O4.
Product Specs
GHRP4, or Growth Hormone Releasing Peptide-4, belongs to a class of synthetic peptides known as Growth Hormone Releasing Peptides (GHRPs). Similar to the naturally occurring Growth Hormone Releasing Hormone (GHRH), GHRPs stimulate the release of growth hormone (GH) from the pituitary gland. GHRP4 is a specific analog of met-enkephalin, incorporating unnatural D-amino acids in its structure. These modifications eliminate opioid activity while preserving its potent GH-releasing properties. Unlike GHRH, GHRP4 exerts its effects through a distinct mechanism, binding to the ghrelin receptor rather than the GHRH receptor.
Growth Hormone Releasing Peptide-4 Synthetic is a single chain polypeptide, devoid of any glycosylation. It comprises 4 amino acids, resulting in a molecular weight of 607.73 Daltons. The molecular formula for GHRP4 is C34H37N7O4.
The peptide is lyophilized without the addition of any excipients.
To reconstitute lyophilized GHRP4, it is recommended to dissolve it in sterile 18MΩ-cm H2O at a concentration not less than 100 µg/ml. This solution can be further diluted in other aqueous solutions as needed.
Lyophilized GHRP4 remains stable at room temperature for up to 3 weeks. However, for long-term storage, it is recommended to store it desiccated below -18°C. After reconstitution, GHRP4 should be stored at 4°C for a period of 2-7 days. For extended storage, freezing at -18°C is recommended, ideally with the addition of a carrier protein such as 0.1% HSA or BSA. Avoid repeated freeze-thaw cycles.
The purity of the peptide is greater than 97.0%, as determined by Reverse-Phase High-Performance Liquid Chromatography (RP-HPLC).
GHRP-4, GHRP4.
(D-Trp)-Ala-Trp-(D-Phe)-NH2.
Product Science Overview
Growth Hormone Releasing Peptide-4 (GHRP-4) is a synthetic peptide that belongs to the family of growth hormone-releasing peptides (GHRPs). These peptides are known for their ability to stimulate the release of growth hormone (GH) from the pituitary gland. GHRP-4, like other GHRPs, has been developed to mimic the action of endogenous growth hormone-releasing hormone (GHRH) and to enhance the secretion of GH.
GHRP-4 is a synthetic analog of met-enkephalin, a naturally occurring peptide. It contains unnatural D-amino acids, which contribute to its stability and biological activity. The peptide sequence of GHRP-4 is designed to interact with specific receptors on the pituitary gland, leading to the release of GH.
The primary mechanism of action of GHRP-4 involves binding to the growth hormone secretagogue receptor (GHS-R) on the pituitary gland. This binding triggers a cascade of intracellular events that result in the release of GH. The process is mediated through the activation of the cAMP-dependent pathway, which involves the stimulation of adenylyl cyclase and the subsequent increase in intracellular cyclic adenosine monophosphate (cAMP) levels. This leads to the activation of protein kinase A (PKA) and the phosphorylation of transcription factors that enhance GH gene expression .
The release of GH stimulated by GHRP-4 has several physiological effects, including:
- Promotion of Growth: GH plays a crucial role in promoting linear growth in children and adolescents by stimulating the growth of bones and cartilage.
- Metabolic Regulation: GH influences the metabolism of proteins, carbohydrates, and lipids. It promotes protein synthesis, enhances lipolysis (breakdown of fats), and affects glucose metabolism.
- Muscle and Tissue Repair: GH is involved in the repair and regeneration of tissues, including muscle tissue. It enhances the proliferation and differentiation of muscle cells, contributing to muscle growth and recovery.
- Immune Function: GH has been shown to modulate immune function, enhancing the activity of certain immune cells and promoting the production of cytokines.
GHRP-4 and other GHRPs have been investigated for their potential therapeutic applications. Some of the areas of interest include:
- Growth Disorders: GHRPs may be used to treat growth hormone deficiency and other growth disorders in children and adults.
- Aging and Longevity: There is interest in the use of GHRPs for anti-aging purposes, as GH levels decline with age. However, the use of GH for anti-aging is controversial and not approved by regulatory authorities.
- Muscle Wasting Conditions: GHRPs may be beneficial in conditions characterized by muscle wasting, such as cachexia and sarcopenia.
- Metabolic Disorders: GHRPs have potential applications in the treatment of metabolic disorders, including obesity and insulin resistance.
While GHRP-4 and other GHRPs have shown promise in various applications, their use is not without risks. Potential side effects include:
- Carcinogenic Potential: There is concern that GHRPs may promote the growth of certain cancers by stimulating GH release.
- Hormonal Imbalance: Excessive use of GHRPs can lead to hormonal imbalances and adverse effects on the endocrine system.
- Regulatory Status: The use of GHRPs is regulated, and they are banned by organizations such as the World Anti-Doping Agency (WADA) for use in competitive sports .
