Ipamorelin

Ipamorelin
Cat. No.
BT13539
Source
Synonyms

Ipamorelin

Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
Purity

Greater than 97.0% as determined by analysis by RP-HPLC.

Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description

Ipamorelin Synthetic is a single, non-glycosylated polypeptide chain containing 4 amino acids, having a molecular mass of 711.85 Dalton and a Molecular formula of C38H49N9O5.

Product Specs

Introduction
Ipamorelin is a peptide that selectively activates the ghrelin/growth hormone secretagogue receptor, leading to increased growth hormone production. Derived from GHRP1, this pentapeptide has been shown to significantly elevate plasma growth hormone levels in both animal and human studies. Similar to pralmorelin and GHRP-6, ipamorelin does not impact prolactin, FSH, LH, or TSH levels. Notably, unlike GHRP2 and GHRP6 but similar to growth hormone-releasing hormone (GHRH), ipamorelin does not stimulate the release of adrenocorticotropic hormone (ACTH) or cortisol. Its action is highly specific to inducing GH secretion.
Description
Ipamorelin Synthetic is a single, unbranched chain of 4 amino acids, devoid of any carbohydrate modifications. It has a molecular weight of 711.85 Daltons and is represented by the molecular formula C38H49N9O5.
Physical Appearance
White, freeze-dried powder that has been sterilized by filtration.
Formulation
The protein was freeze-dried without the addition of any other substances.
Solubility
To reconstitute the freeze-dried Ipamorelin, it is recommended to dissolve it in sterile 18MΩ-cm H2O at a concentration of at least 100 µg/ml. This solution can be further diluted with other aqueous solutions as needed.
Stability
While freeze-dried Ipamorelin remains stable at room temperature for up to 3 weeks, it is best stored in a dry state below -18°C. Once reconstituted, Ipamorelin should be kept at 4°C for no longer than 2-7 days. For long-term storage, freezing below -18°C is recommended, preferably with the addition of a carrier protein (0.1% HSA or BSA). Avoid repeated freezing and thawing cycles.
Purity
Exceeds 97.0% purity as determined by RP-HPLC analysis.
Synonyms

Ipamorelin

Amino Acid Sequence

Aib-His-D-2-Nal-D-Phe-Lys-NH2.

Product Science Overview

Mechanism of Action

Ipamorelin functions by mimicking the action of ghrelin, a natural hormone in the body. It selectively binds to the growth hormone secretagogue receptor (GHS-R1a), which triggers the release of GH . This process influences various anabolic activities, including appetite regulation, fat metabolism, and overall energy usage .

Benefits and Uses

Ipamorelin is known for its numerous potential benefits, particularly in the fields of fitness, anti-aging, and overall well-being. Some of the key benefits include:

  • Increased Muscle Mass: Ipamorelin promotes the growth of new muscle fibers and aids in muscle recovery .
  • Improved Bone Density: It has been shown to enhance bone cell formation, which can help reduce bone deterioration due to aging .
  • Fat Metabolism: Ipamorelin aids in fat loss by increasing natural GH production, which influences fat metabolism .
  • Enhanced Recovery: It supports quicker and more effective healing from injuries by aiding in the repair of damaged muscle fibers .
  • Anti-Aging: Higher GH levels induced by Ipamorelin contribute to deep sleep and may delay the aging process .
Preparation Methods

Ipamorelin is synthesized in laboratories through solid-phase peptide synthesis (SPPS). This method involves the sequential addition of amino acids to a growing peptide chain, which is anchored to a solid resin. The process ensures high purity and yield of the final peptide product .

Chemical Reactions and Analysis

Ipamorelin’s chemical structure allows it to undergo various reactions that are typical for peptides. It is stable under physiological conditions, which makes it suitable for therapeutic use. Analytical techniques such as high-performance liquid chromatography (HPLC) and mass spectrometry (MS) are commonly used to verify the purity and identity of Ipamorelin .

Safety and Side Effects

While Ipamorelin is generally considered safe when used under medical supervision, it is essential to be aware of potential side effects. These may include headaches, dizziness, and localized pain at the injection site . It is crucial to follow proper dosage guidelines and consult with a healthcare professional before using Ipamorelin.

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THE BIOTEK
THE BioTek is a global biotech company offering highly purified proteins for research in cancer, apoptosis, development, endocrinology, immunology, neuroscience, proteases, and stem cells.
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