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Monoclonal Antibodies

Other Monoclonal Antibodies

Anti Human Lymphocyte

Anti Mouse Cytokine

Anti Human Cytokine

Anti Mouse Lymphocyte

Anti-GST Monoclonal

Anti Viral Monoclonal

Anti Human Heat Shock Protein

Anti Human Enzyme

Product List

TBCB Antibody

Tubulin Folding Cofactor B, Mouse Anti Human

Shipped with Ice Packs

Cat. No.

BT1169

Source

Appearance

Sterile filtered colorless solution.

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TBCEL Antibody

Tubulin Folding Cofactor E-Like, Mouse Anti Human

Shipped with Ice Packs

Cat. No.

BT1258

Source

Appearance

Sterile filtered colorless solution.

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Tetanus antibody

Tetanus toxoid scFv Recombinant antibody

Tetanus toxin is the neurotoxin produced by the vegetative spore of Clostridium tetani in anaerobic conditions, causing tetanus.
Recombinant Anti Tetanus produced in E.Coli is a non-glycosylated, polypeptide chain containing a hexahistidine tag and having a molecular weight of 37 kDa.
Tetanus Antibody is purified by proprietary chromatographic techniques.

Shipped with Ice Packs

Cat. No.

BT1312

Source

Escherichia Coli.

Appearance

Sterile Filtered clear solution.

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TLR2 Antibody

Toll-like receptor 2, Mouse Anti Human

Shipped with Ice Packs

Cat. No.

BT1403

Source

Appearance

Sterile filtered colorless solution.

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TLR7 Antibody

Toll-like receptor 7, Mouse Anti Human

Shipped with Ice Packs

Cat. No.

BT1486

Source

Appearance

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TMEFF2 Antibody

Tomoregulin-2, Mouse Anti Human

Shipped with Ice Packs

Cat. No.

BT1556

Source

Appearance

Sterile filtered colorless solution.

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TNNI1 Antibody

Troponin I Type 1, Mouse Anti Human

Shipped with Ice Packs

Cat. No.

BT1656

Source

Appearance

Sterile Filtered colorless solution.

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TNNI1 Paired Antibody

Mouse Anti Human Troponin I Type 1 Paired

TNNI1 gold conjugation antibody and TNNI1 capture antibody are used to develop rapid test for TNNI1 rapid test. Please note that when ordering for example: 50µg antibody we ship 25µg from each of the antibodies (50µg in total).

Shipped with Ice Packs

Cat. No.

BT1728

Source

Appearance

2 vials of sterile Filtered clear colorless solution.

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TNNI3 Paired Antibody

Mouse Anti Human Troponin I Type 3 Paired

TNNI3 Paired antibodies, coating and conjugating are used for lateral flow immunoassay.

Please note that when ordering for example: 100µg antibody we ship 50µg from each of the antibodies (100µg in total).

Shipped with Ice Packs

Cat. No.

BT1852

Source

Appearance

2 vials of sterile filtered clear colorless solution.

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TOLLIP Antibody

Toll-interacting protein, Mouse Anti Human

Shipped with Ice Packs

Cat. No.

BT1935

Source

Appearance

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Introduction

Definition and Classification

Monoclonal antibodies (mAbs) are laboratory-produced molecules engineered to serve as substitute antibodies that can restore, enhance, or mimic the immune system’s attack on cells. They are produced by identical immune cells that are all clones of a unique parent cell. Monoclonal antibodies can be classified based on their source and structure:

Murine mAbs: Derived from mouse cells.
Chimeric mAbs: Contain both human and mouse components.
Humanized mAbs: Mostly human, with only small mouse-derived components.
Human mAbs: Fully human antibodies.

Biological Properties

Monoclonal antibodies exhibit several key biological properties:

Protein Sequence: Identical protein sequences and antigen-binding sites.
Expression Patterns: Produced by B lymphocytes and expressed in hybridoma cells.
Tissue Distribution: Can be designed to target specific tissues or cells, such as cancer cells.

Biological Functions

Monoclonal antibodies play crucial roles in the immune system:

Pathogen Recognition: Bind to specific antigens on pathogens, marking them for destruction.
Immune Response: Enhance the immune system’s ability to fight infections and diseases.
Therapeutic Functions: Used in treating various diseases, including cancer, autoimmune disorders, and infectious diseases.

Modes of Action

Monoclonal antibodies interact with other molecules and cells through various mechanisms:

Binding Partners: Bind to specific antigens on target cells.
Downstream Signaling Cascades: Trigger immune responses by activating immune cells and complement systems.
Effector Functions: Engage Fc receptors on immune cells, leading to cell-mediated cytotoxicity.

Regulatory Mechanisms

The expression and activity of monoclonal antibodies are tightly regulated:

Transcriptional Regulation: Controlled by specific transcription factors that regulate the expression of antibody genes.
Post-Translational Modifications: Undergo modifications such as glycosylation, which can affect their stability and function.

Applications

Monoclonal antibodies have a wide range of applications in biomedical research and medicine:

Diagnostic Tools: Used in assays to detect specific antigens in samples.
Therapeutic Strategies: Employed in the treatment of cancers, autoimmune diseases, and infectious diseases.
Biomedical Research: Serve as tools to study cellular processes and disease mechanisms.

Role in the Life Cycle

Monoclonal antibodies play roles throughout the life cycle:

Development: Used in prenatal diagnostics and treatments.
Aging: Help manage age-related diseases such as cancer and Alzheimer’s.
Disease: Provide targeted therapies for various diseases, improving patient outcomes.