TMEFF2 Antibody

Tomoregulin-2, Mouse Anti Human
Cat. No.
BT1556
Source
Synonyms
TMEFF2, Tomoregulin-2, Transmembrane protein with EGF-like and two follistatin-like domains, Hyperplastic polyposis protein 1, HPP1, TENB2, TPEF, TR, CT120.2.
Appearance
Sterile filtered colorless solution.
Purity
Usage
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Description

Product Specs

Introduction
TMEFF2 is a gene that codes for a plasma membrane protein. This protein contains two follistatin-like domains and one epidermal growth factor-like domain. TMEFF2 is found in limited quantities in normal tissue but is highly expressed in prostate cancer. When released from the cell surface, TMEFF2 can increase cancer cell proliferation, likely by activating ERK1/2 phosphorylation. TMEFF2 expression is reduced in tumor cell lines when methylation levels are high in the gene's 5' region.
Physical Appearance
A clear, colorless solution that has been sterilized by filtration.
Formulation
The solution contains 1mg/ml of TMEFF2 antibody dissolved in a phosphate-buffered saline (PBS) solution at a pH of 7.4 and preserved with 0.1% sodium azide.
Storage Procedures
For short-term storage (up to 1 month), keep the antibody solution at 4°C. For long-term storage, store at -20°C. Avoid repeated freezing and thawing cycles to maintain antibody stability.
Stability / Shelf Life
The antibody is stable for 12 months when stored at -20°C and for 1 month at 4°C.
Applications
This TMEFF2 antibody has been validated for use in ELISA, Western blot, and immunohistochemistry applications. It demonstrates high specificity and reactivity. However, to achieve optimal results, it is recommended to titrate the antibody for each specific application. The recommended dilution range for Western blot analysis is 1:1,000 to 1:2,000, while for immunohistochemistry, it is 1:50 to 1:100. A starting dilution of 1:1,000 for Western blot and 1:50 for immunohistochemistry is a good starting point.
Synonyms
TMEFF2, Tomoregulin-2, Transmembrane protein with EGF-like and two follistatin-like domains, Hyperplastic polyposis protein 1, HPP1, TENB2, TPEF, TR, CT120.2.
Purification Method
TMEFF2 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Type
Mouse Anti Human Monoclonal.
Clone
PJ4B6AT.
Immunogen
Anti-human TMEFF2 mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human TMEFF2 amino acids 41-150 purified from E. coli.
Ig Subclass
Mouse IgG2b heavy chain and κ light chain.

Product Science Overview

Structure and Function

Tomoregulin-2 is a transmembrane protein that contains EGF-like and follistatin-like domains. These domains are involved in various cellular processes, including cell signaling and regulation of cell growth. The protein has been shown to function as both an oncogene and a tumor suppressor, depending on the cellular context . This dual role suggests that Tomoregulin-2 may play a complex role in cancer biology, particularly in prostate cancer cell invasion .

Mouse Anti Human Tomoregulin-2 Antibody

The Mouse Anti Human Tomoregulin-2 Antibody is a monoclonal antibody derived from mouse and is used to detect human TMEFF2 in various applications, including Western blotting and immunohistochemistry . This antibody is highly specific and can be used to study the expression and localization of TMEFF2 in human tissues.

  • Immunogen: The antibody is generated using a full-length human recombinant protein of TMEFF2 produced in HEK293T cells .
  • Applications: The antibody is validated for use in Western blotting, immunohistochemistry, and immunohistochemistry-paraffin .
  • Storage: The antibody should be stored at -20°C to avoid freeze-thaw cycles .
Research and Clinical Implications

Research on Tomoregulin-2 has significant implications for understanding cancer biology, particularly in the context of prostate cancer. The ability of Tomoregulin-2 to act as both an oncogene and a tumor suppressor highlights its potential as a therapeutic target. Studies using the Mouse Anti Human Tomoregulin-2 Antibody can provide insights into the protein’s role in cancer progression and may lead to the development of new diagnostic and therapeutic strategies.

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