Chemokines
Product List
MCP 5 Mouse
Monocyte Chemotactic Protein-5 Mouse Recombinant (CCL12)
The MCP5 is purified by proprietary chromatographic techniques.
MCP1 Human, HEK
Monocyte Chemotactic Protein-1/MCAF (CCL2) Human Recombinant, HEK
MCP1 Human HEK Recombinant produced in HEK293 Cells is a single, glycosylated polypeptide chain containing 82 amino acids (24-99a.a) and having a molecular mass of 9.5 kDa.
MCP1 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
MCP1 Rat, Sf9
Monocyte Chemotactic Protein-1 Rat Recombinant, Sf9
MCP1 Rat Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 134 amino acids (24-148 aa) and having a molecular mass of 15.1kDa.
MCP1 is fused to a 6 amino acid His tag at C-terminus and purified by proprietary chromatographic techniques.
Sf9, Baculovirus cells
Sterile filtered colorless solution.
MCP 1 Human
Monocyte Chemotactic Protein-1 Human Recombinant (CCL2)
The MCP-1 is purified by proprietary chromatographic techniques.
MCP 1 Human, His
Monocyte Chemotactic Protein-1 Human Recombinant (CCL2), His Tag
The MCP-1 is fused to 20 amino acids His-Tag at N-terminus and purified by proprietary chromatographic techniques.
MCP 1 Mouse
Monocyte Chemotactic Protein-1 Mouse Recombinant (CCL2)
The MCP-1 is purified by proprietary chromatographic techniques.
Introduction
Monocyte chemoattractant proteins (MCPs) are a subset of the CC chemokine family, which are small cytokines involved in the chemotaxis of immune cells. The MCP family includes CCL2, CCL7, CCL8, CCL12, and CCL13. These proteins play crucial roles in recruiting monocytes, memory T cells, and dendritic cells to sites of inflammation or injury .
Key Biological Properties: MCPs are characterized by their ability to attract monocytes and other immune cells. They are small proteins, typically around 8-15 kDa in size, and contain conserved cysteine residues that form disulfide bonds .
Expression Patterns: MCPs are expressed by a variety of cell types, including endothelial cells, fibroblasts, smooth muscle cells, monocytes, macrophages, and dendritic cells .
Tissue Distribution: MCPs are found in many tissues, particularly at sites of inflammation. They are also present in the central nervous system, where they are involved in neuroinflammatory processes .
Primary Biological Functions: MCPs primarily function as chemotactic agents, guiding the migration of monocytes and other immune cells to sites of inflammation. They play a significant role in immune responses and pathogen recognition .
Role in Immune Responses: MCPs are involved in the recruitment of immune cells to sites of infection or injury, facilitating the clearance of pathogens and the resolution of inflammation .
Pathogen Recognition: By attracting immune cells to sites of infection, MCPs help the body recognize and respond to pathogens more effectively .
Mechanisms with Other Molecules and Cells: MCPs interact with specific receptors on the surface of target cells, primarily CCR2 and CCR4. These interactions trigger downstream signaling cascades that lead to cell migration and activation .
Binding Partners: MCPs bind to chemokine receptors such as CCR2 and CCR4, which are expressed on the surface of monocytes, macrophages, and other immune cells .
Downstream Signaling Cascades: Upon binding to their receptors, MCPs activate G-protein coupled signaling pathways, leading to changes in cell behavior, including increased motility and cytokine production .
Expression and Activity Control: The expression of MCPs is regulated at both the transcriptional and post-transcriptional levels. Various cytokines and growth factors, such as IL-1, TNF-α, and PDGF, can induce MCP expression .
Transcriptional Regulation: MCP gene expression is controlled by transcription factors such as NF-κB, which bind to promoter regions of MCP genes and enhance their transcription in response to inflammatory stimuli .
Post-Translational Modifications: MCPs can undergo post-translational modifications, such as glycosylation, which can affect their stability and activity .
Biomedical Research: MCPs are widely studied in the context of inflammation, cancer, and neurodegenerative diseases. They serve as biomarkers for disease progression and therapeutic targets .
Diagnostic Tools: Elevated levels of MCPs in biological fluids can indicate the presence of inflammatory or infectious diseases, making them useful diagnostic markers .
Therapeutic Strategies: Targeting MCPs or their receptors has therapeutic potential in treating inflammatory diseases, cancer, and neurodegenerative disorders .
Development: MCPs play a role in embryonic development by regulating the migration of immune cells and contributing to tissue remodeling .
Aging: As organisms age, the expression of MCPs can increase, contributing to age-related inflammation and diseases such as Alzheimer’s and cardiovascular diseases .
Disease: MCPs are involved in the pathogenesis of various diseases, including cancer, rheumatoid arthritis, and neurodegenerative disorders. They contribute to disease progression by promoting inflammation and immune cell infiltration .
