Chemokines
Product List
CTACK Human
CTACK Human Recombinant (CCL27)
CTACK Mouse
CTACK Mouse Recombinant (CCL27)
The CTACK is purified by proprietary chromatographic techniques.
Introduction
CTACK, also known as CCL27 (C-C motif chemokine ligand 27), is a member of the CC chemokine family. Chemokines are small cytokines or signaling proteins secreted by cells. CCL27 is specifically involved in the chemotaxis of skin-associated memory T lymphocytes and plays a crucial role in T cell-mediated inflammation of the skin .
Key Biological Properties: CCL27 is a chemokine that binds to the chemokine receptor CCR10. It is characterized by the presence of two adjacent cysteines .
Expression Patterns: CCL27 is predominantly expressed by keratinocytes in the skin. It is also found in other tissues such as the gonads, thymus, and placenta .
Tissue Distribution: The highest expression of CCL27 is observed in the skin, particularly in the basal keratinocytes. It is also present in the gonads, thymus, and placenta .
Primary Biological Functions: CCL27 is primarily involved in the homing of memory T lymphocytes to the skin. It plays a significant role in T cell-mediated inflammation and immune responses in the skin .
Role in Immune Responses: CCL27 attracts CCR10-expressing skin-homing memory T cells, thereby contributing to the immune surveillance and inflammatory responses in the skin .
Pathogen Recognition: While CCL27 itself is not directly involved in pathogen recognition, it facilitates the recruitment of immune cells that are essential for recognizing and responding to pathogens .
Mechanisms with Other Molecules and Cells: CCL27 exerts its effects by binding to the chemokine receptor CCR10 on the surface of target cells. This interaction triggers downstream signaling pathways that lead to the migration of T cells to the skin .
Binding Partners: The primary binding partner of CCL27 is the chemokine receptor CCR10 .
Downstream Signaling Cascades: Upon binding to CCR10, CCL27 activates G protein-coupled receptor signaling pathways, leading to the reorganization of the actin cytoskeleton and the directed migration of T cells .
Regulatory Mechanisms: The expression and activity of CCL27 are regulated at multiple levels, including transcriptional and post-translational modifications .
Transcriptional Regulation: The transcription of the CCL27 gene is controlled by various transcription factors that respond to inflammatory signals .
Post-Translational Modifications: CCL27 undergoes post-translational modifications that can affect its stability, activity, and interactions with other molecules .
Biomedical Research: CCL27 is used in research to study skin inflammation, immune responses, and chemokine signaling pathways .
Diagnostic Tools: Elevated levels of CCL27 in serum can serve as a biomarker for certain inflammatory skin diseases, such as atopic dermatitis and psoriasis .
Therapeutic Strategies: Targeting the CCL27-CCR10 axis holds potential for developing therapies for inflammatory skin diseases and certain cancers .
Development: CCL27 is involved in the development of skin-resident immune cells and the establishment of immune homeostasis in the skin .
Aging: The expression of CCL27 may change with aging, potentially affecting skin immunity and inflammation .
Disease: Dysregulation of CCL27 expression is associated with various skin diseases, including atopic dermatitis, psoriasis, and skin cancers .
