Monoclonal Antibodies
Product List
Rabbit SARS CoV-2 IgG S1
Recombinant Anti Rabbit SARS CoV-2 IgG Spike S1
Recombinant Anti Rabbit SARS CoV-2 IgG Kappa Spike S1 is a recombinant monoclonal antibody derived from HEK293 cells which recognizes the SARS-CoV and SARS-CoV-2 Spike glycoprotein. CoV-2 IgG S1 Rabbit Antibody binds to both SARS-CoV and SARS-CoV-2 with high affinity at amino acids 318-510 (RBD, Receptor Binding Domain) in the S1 subunit of the Spike protein. This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format.
RSV Paired Antibody
Mouse Anti Human Respiratory Syncytial Virus
S.typhi Paired Antibody
Mouse Anti Salmonella Typhi Paired
Typhi antibodies, capture and conjugating, target S. Typhi Outer Membrane Protein and S.Typhi specific polysaccharide respectively.
This Antibody is used both as conjugate and capture.
SARS CoV-2 IgG S1
Recombinant Anti Human SARS CoV-2 IgG Spike S1, Monoclonal
Recombinant Anti Human SARS CoV-2 IgG1 Kappa Spike S1 is a recombinant monoclonal antibody derived from HEL293 cells which recognizes the SARS-CoV and SARS-CoV-2 Spike glycoprotein. CoV-2 IgG S1 Antibody binds to both SARS-CoV and SARS-CoV-2 with high affinity at amino acids 318-510 (RBD, Receptor Binding Domain) in the S1 subunit of the Spike protein.
SARS CoV-2 IgM S1
Recombinant Anti Human SARS CoV-2 IgM Spike S1
Recombinant Anti Human SARS CoV-2 IgM Kappa Spike S1 is a recombinant monoclonal antibody derived from HEK293 cells which recognizes the SARS-CoV and SARS-CoV-2 Spike glycoprotein. CoV-2 IgM S1 Antibody binds to both SARS-CoV and SARS-CoV-2 with high affinity at amino acids 318-510 (RBD, Receptor Binding Domain) in the S1 subunit of the Spike protein.
SARS MERS Spike S1
Mouse Anti SARS MERS Spike S1
SARS MERS Spike-S1 antibody is specific for the S1 domain of the spike protein of the MERS virus.
SARS Nucleocapsid Biotin Antibody
Mouse Anti SARS Nucleocapsid Biotinylated
SARS Nucleoprotein Biotinylated antibody clone PT3851 is specific for the nucleocapsid SARS-CoV protein and recognizes the nucleoprotein of SARS-CoV-2 by ELISA.
Introduction
Monoclonal antibodies (mAbs) are laboratory-produced molecules engineered to serve as substitute antibodies that can restore, enhance, or mimic the immune system’s attack on cells. They are designed to bind to antigens that are generally more specific than polyclonal antibodies . Anti-viral monoclonal antibodies are a subset of mAbs specifically designed to target and neutralize viruses. These antibodies can be classified based on their source (e.g., murine, chimeric, humanized, or fully human) and their mechanism of action (e.g., neutralizing vs. non-neutralizing) .
Anti-viral monoclonal antibodies exhibit several key biological properties:
- Expression Patterns: These antibodies are typically produced in mammalian cell lines such as CHO (Chinese Hamster Ovary) cells, which allow for proper folding and post-translational modifications .
- Tissue Distribution: Once administered, mAbs distribute throughout the body, with a significant presence in the bloodstream and tissues where the targeted virus is likely to be found .
The primary biological functions of anti-viral monoclonal antibodies include:
Anti-viral monoclonal antibodies operate through several mechanisms:
- Binding Partners: They bind to viral surface proteins, such as the spike protein of SARS-CoV-2, blocking the virus from attaching to host cell receptors .
- Downstream Signaling Cascades: Upon binding to the virus, these antibodies can trigger downstream signaling pathways that lead to the activation of immune cells and the destruction of the virus .
The expression and activity of anti-viral monoclonal antibodies are tightly regulated:
- Transcriptional Regulation: The genes encoding these antibodies are often placed under the control of strong promoters to ensure high levels of expression in production cell lines .
- Post-Translational Modifications: These antibodies undergo various post-translational modifications, such as glycosylation, which are crucial for their stability and function .
Anti-viral monoclonal antibodies have a wide range of applications:
- Biomedical Research: They are used to study viral infections and the immune response to these infections .
- Diagnostic Tools: mAbs are employed in diagnostic assays to detect the presence of viruses in clinical samples .
- Therapeutic Strategies: These antibodies are used as treatments for viral infections, either alone or in combination with other antiviral agents .
Throughout the life cycle, anti-viral monoclonal antibodies play crucial roles:
